WDR35-PUM2 Fusion FISH Probe
The WDR35-PUM2 Fusion FISH Probe is used to confirm a fusion of the WDR35 and PUM2 genes. The fusion of the WDR35 and PUM2 genes has been associated with Lung Squamous Cell Carcinoma, and Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| WDR35-PUM2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| WDR35-PUM2-20-RERE | 20 (40 μL) | 200 μL |
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| WDR35-PUM2-20-REOR | 20 (40 μL) | 200 μL |
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| WDR35-PUM2-20-REGO | 20 (40 μL) | 200 μL |
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| WDR35-PUM2-20-REGR | 20 (40 μL) | 200 μL |
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| WDR35-PUM2-20-REAQ | 20 (40 μL) | 200 μL |
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| WDR35-PUM2-20-ORRE | 20 (40 μL) | 200 μL |
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| WDR35-PUM2-20-OROR | 20 (40 μL) | 200 μL |
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| WDR35-PUM2-20-ORGO | 20 (40 μL) | 200 μL |
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| WDR35-PUM2-20-ORAQ | 20 (40 μL) | 200 μL |
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| WDR35-PUM2-20-GORE | 20 (40 μL) | 200 μL |
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| WDR35-PUM2-20-GOOR | 20 (40 μL) | 200 μL |
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| WDR35-PUM2-20-GOGO | 20 (40 μL) | 200 μL |
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| WDR35-PUM2-20-GOGR | 20 (40 μL) | 200 μL |
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| WDR35-PUM2-20-GOAQ | 20 (40 μL) | 200 μL |
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| WDR35-PUM2-20-GRRE | 20 (40 μL) | 200 μL |
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| WDR35-PUM2-20-GROR | 20 (40 μL) | 200 μL |
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| WDR35-PUM2-20-GRGO | 20 (40 μL) | 200 μL |
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| WDR35-PUM2-20-GRGR | 20 (40 μL) | 200 μL |
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| WDR35-PUM2-20-GRAQ | 20 (40 μL) | 200 μL |
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| WDR35-PUM2-20-AQRE | 20 (40 μL) | 200 μL |
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| WDR35-PUM2-20-AQOR | 20 (40 μL) | 200 μL |
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| WDR35-PUM2-20-AQGO | 20 (40 μL) | 200 μL |
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| WDR35-PUM2-20-AQGR | 20 (40 μL) | 200 μL |
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| WDR35-PUM2-20-AQAQ | 20 (40 μL) | 200 μL |
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PUM2 Gene Summary
This gene encodes a protein that belongs to a family of RNA-binding proteins. The encoded protein functions as a translational repressor during embryonic development and cell differentiation. This protein is also thought to be a positive regulator of cell proliferation in adipose-derived stem cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Name: Pumilio RNA Binding Family Member 2
Chromosome: CHR2: 20448452 -20527144
Locus: 2p24.1
WDR35 Gene Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Two patients with Sensenbrenner syndrome / cranioectodermal dysplasia (CED) were identified with mutations in this gene, consistent with a possible ciliary function.[provided by RefSeq, Sep 2010]
Gene Name: WD Repeat Domain 35
Chromosome: CHR2: 20110028 -20189884
Locus: 2p24.1
Gene Diseases
The WDR35 PUM2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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