WDR34-NDUFV1 Fusion FISH Probe
The WDR34-NDUFV1 Fusion FISH Probe is used to confirm a fusion of the WDR34 and NDUFV1 genes. The fusion of the WDR34 and NDUFV1 genes has been associated with Thymoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| WDR34-NDUFV1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| WDR34-NDUFV1-20-RERE | 20 (40 μL) | 200 μL |
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| WDR34-NDUFV1-20-REOR | 20 (40 μL) | 200 μL |
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| WDR34-NDUFV1-20-REGO | 20 (40 μL) | 200 μL |
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| WDR34-NDUFV1-20-REGR | 20 (40 μL) | 200 μL |
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| WDR34-NDUFV1-20-REAQ | 20 (40 μL) | 200 μL |
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| WDR34-NDUFV1-20-ORRE | 20 (40 μL) | 200 μL |
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| WDR34-NDUFV1-20-OROR | 20 (40 μL) | 200 μL |
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| WDR34-NDUFV1-20-ORGO | 20 (40 μL) | 200 μL |
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| WDR34-NDUFV1-20-ORAQ | 20 (40 μL) | 200 μL |
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| WDR34-NDUFV1-20-GORE | 20 (40 μL) | 200 μL |
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| WDR34-NDUFV1-20-GOOR | 20 (40 μL) | 200 μL |
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| WDR34-NDUFV1-20-GOGO | 20 (40 μL) | 200 μL |
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| WDR34-NDUFV1-20-GOGR | 20 (40 μL) | 200 μL |
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| WDR34-NDUFV1-20-GOAQ | 20 (40 μL) | 200 μL |
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| WDR34-NDUFV1-20-GRRE | 20 (40 μL) | 200 μL |
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| WDR34-NDUFV1-20-GROR | 20 (40 μL) | 200 μL |
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| WDR34-NDUFV1-20-GRGO | 20 (40 μL) | 200 μL |
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| WDR34-NDUFV1-20-GRGR | 20 (40 μL) | 200 μL |
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| WDR34-NDUFV1-20-GRAQ | 20 (40 μL) | 200 μL |
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| WDR34-NDUFV1-20-AQRE | 20 (40 μL) | 200 μL |
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| WDR34-NDUFV1-20-AQOR | 20 (40 μL) | 200 μL |
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| WDR34-NDUFV1-20-AQGO | 20 (40 μL) | 200 μL |
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| WDR34-NDUFV1-20-AQGR | 20 (40 μL) | 200 μL |
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| WDR34-NDUFV1-20-AQAQ | 20 (40 μL) | 200 μL |
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NDUFV1 Gene Summary
The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
Gene Name: NADH:ubiquinone Oxidoreductase Core Subunit V1
Chromosome: CHR11: 67374322 -67380012
Locus: 11q13.2
WDR34 Gene Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Defects in this gene are a cause of short-rib thoracic dysplasia 11 with or without polydactyly. [provided by RefSeq, Mar 2014]
Gene Name: WD Repeat Domain 34
Chromosome: CHR9: 131395939 -131419129
Locus: 9q34.11
Gene Diseases
The WDR34 NDUFV1 Fusion has been associated with the following diseases:
| Disease Name |
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| Thymoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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