WDR18-H2AFX Fusion FISH Probe
The WDR18-H2AFX Fusion FISH Probe is used to confirm a fusion of the WDR18 and H2AFX genes. The fusion of the WDR18 and H2AFX genes has been associated with Acute Myeloid Leukemia. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| WDR18-H2AFX-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| WDR18-H2AFX-20-RERE | 20 (40 μL) | 200 μL |
|
|
| WDR18-H2AFX-20-REOR | 20 (40 μL) | 200 μL |
|
|
| WDR18-H2AFX-20-REGO | 20 (40 μL) | 200 μL |
|
|
| WDR18-H2AFX-20-REGR | 20 (40 μL) | 200 μL |
|
|
| WDR18-H2AFX-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| WDR18-H2AFX-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| WDR18-H2AFX-20-OROR | 20 (40 μL) | 200 μL |
|
|
| WDR18-H2AFX-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| WDR18-H2AFX-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| WDR18-H2AFX-20-GORE | 20 (40 μL) | 200 μL |
|
|
| WDR18-H2AFX-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| WDR18-H2AFX-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| WDR18-H2AFX-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| WDR18-H2AFX-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| WDR18-H2AFX-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| WDR18-H2AFX-20-GROR | 20 (40 μL) | 200 μL |
|
|
| WDR18-H2AFX-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| WDR18-H2AFX-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| WDR18-H2AFX-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| WDR18-H2AFX-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| WDR18-H2AFX-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| WDR18-H2AFX-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| WDR18-H2AFX-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| WDR18-H2AFX-20-AQAQ | 20 (40 μL) | 200 μL |
|
H2AFX Gene Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Oct 2015]
Gene Name: H2A Histone Family Member X
Chromosome: CHR11: 118964584 -118966177
Locus: 11q23.3
WDR18 Gene Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]
Gene Name: WD Repeat Domain 18
Chromosome: CHR19: 984327 -994569
Locus: 19p13.3
Gene Diseases
The WDR18 H2AFX Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Acute Myeloid Leukemia |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|