WDFY3-PLAGL1 Fusion FISH Probe
The WDFY3-PLAGL1 Fusion FISH Probe is used to confirm a fusion of the WDFY3 and PLAGL1 genes. The fusion of the WDFY3 and PLAGL1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| WDFY3-PLAGL1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| WDFY3-PLAGL1-20-RERE | 20 (40 μL) | 200 μL |
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| WDFY3-PLAGL1-20-REOR | 20 (40 μL) | 200 μL |
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| WDFY3-PLAGL1-20-REGO | 20 (40 μL) | 200 μL |
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| WDFY3-PLAGL1-20-REGR | 20 (40 μL) | 200 μL |
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| WDFY3-PLAGL1-20-REAQ | 20 (40 μL) | 200 μL |
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| WDFY3-PLAGL1-20-ORRE | 20 (40 μL) | 200 μL |
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| WDFY3-PLAGL1-20-OROR | 20 (40 μL) | 200 μL |
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| WDFY3-PLAGL1-20-ORGO | 20 (40 μL) | 200 μL |
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| WDFY3-PLAGL1-20-ORAQ | 20 (40 μL) | 200 μL |
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| WDFY3-PLAGL1-20-GORE | 20 (40 μL) | 200 μL |
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| WDFY3-PLAGL1-20-GOOR | 20 (40 μL) | 200 μL |
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| WDFY3-PLAGL1-20-GOGO | 20 (40 μL) | 200 μL |
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| WDFY3-PLAGL1-20-GOGR | 20 (40 μL) | 200 μL |
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| WDFY3-PLAGL1-20-GOAQ | 20 (40 μL) | 200 μL |
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| WDFY3-PLAGL1-20-GRRE | 20 (40 μL) | 200 μL |
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| WDFY3-PLAGL1-20-GROR | 20 (40 μL) | 200 μL |
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| WDFY3-PLAGL1-20-GRGO | 20 (40 μL) | 200 μL |
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| WDFY3-PLAGL1-20-GRGR | 20 (40 μL) | 200 μL |
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| WDFY3-PLAGL1-20-GRAQ | 20 (40 μL) | 200 μL |
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| WDFY3-PLAGL1-20-AQRE | 20 (40 μL) | 200 μL |
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| WDFY3-PLAGL1-20-AQOR | 20 (40 μL) | 200 μL |
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| WDFY3-PLAGL1-20-AQGO | 20 (40 μL) | 200 μL |
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| WDFY3-PLAGL1-20-AQGR | 20 (40 μL) | 200 μL |
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| WDFY3-PLAGL1-20-AQAQ | 20 (40 μL) | 200 μL |
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PLAGL1 Gene Summary
This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015]
Gene Name: PLAG1 Like Zinc Finger 1
Chromosome: CHR6: 144261436 -144385735
Locus: 6q24.2
WDFY3 Gene Summary
This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. [provided by RefSeq, May 2010]
Gene Name: WD Repeat And FYVE Domain Containing 3
Chromosome: CHR4: 85590692 -85887544
Locus: 4q21.23
Gene Diseases
The WDFY3 PLAGL1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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