WDFY3-HNRNPD Fusion FISH Probe
The WDFY3-HNRNPD Fusion FISH Probe is used to confirm a fusion of the WDFY3 and HNRNPD genes. The fusion of the WDFY3 and HNRNPD genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| WDFY3-HNRNPD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| WDFY3-HNRNPD-20-RERE | 20 (40 μL) | 200 μL |
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| WDFY3-HNRNPD-20-REOR | 20 (40 μL) | 200 μL |
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| WDFY3-HNRNPD-20-REGO | 20 (40 μL) | 200 μL |
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| WDFY3-HNRNPD-20-REGR | 20 (40 μL) | 200 μL |
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| WDFY3-HNRNPD-20-REAQ | 20 (40 μL) | 200 μL |
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| WDFY3-HNRNPD-20-ORRE | 20 (40 μL) | 200 μL |
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| WDFY3-HNRNPD-20-OROR | 20 (40 μL) | 200 μL |
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| WDFY3-HNRNPD-20-ORGO | 20 (40 μL) | 200 μL |
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| WDFY3-HNRNPD-20-ORAQ | 20 (40 μL) | 200 μL |
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| WDFY3-HNRNPD-20-GORE | 20 (40 μL) | 200 μL |
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| WDFY3-HNRNPD-20-GOOR | 20 (40 μL) | 200 μL |
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| WDFY3-HNRNPD-20-GOGO | 20 (40 μL) | 200 μL |
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| WDFY3-HNRNPD-20-GOGR | 20 (40 μL) | 200 μL |
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| WDFY3-HNRNPD-20-GOAQ | 20 (40 μL) | 200 μL |
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| WDFY3-HNRNPD-20-GRRE | 20 (40 μL) | 200 μL |
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| WDFY3-HNRNPD-20-GROR | 20 (40 μL) | 200 μL |
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| WDFY3-HNRNPD-20-GRGO | 20 (40 μL) | 200 μL |
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| WDFY3-HNRNPD-20-GRGR | 20 (40 μL) | 200 μL |
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| WDFY3-HNRNPD-20-GRAQ | 20 (40 μL) | 200 μL |
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| WDFY3-HNRNPD-20-AQRE | 20 (40 μL) | 200 μL |
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| WDFY3-HNRNPD-20-AQOR | 20 (40 μL) | 200 μL |
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| WDFY3-HNRNPD-20-AQGO | 20 (40 μL) | 200 μL |
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| WDFY3-HNRNPD-20-AQGR | 20 (40 μL) | 200 μL |
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| WDFY3-HNRNPD-20-AQAQ | 20 (40 μL) | 200 μL |
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HNRNPD Gene Summary
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]
Gene Name: Heterogeneous Nuclear Ribonucleoprotein D
Chromosome: CHR4: 83274466 -83295149
Locus: 4q21.22
WDFY3 Gene Summary
This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. [provided by RefSeq, May 2010]
Gene Name: WD Repeat And FYVE Domain Containing 3
Chromosome: CHR4: 85590692 -85887544
Locus: 4q21.23
Gene Diseases
The WDFY3 HNRNPD Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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