WBP11-LGR5 Fusion FISH Probe
The WBP11-LGR5 Fusion FISH Probe is used to confirm a fusion of the WBP11 and LGR5 genes. The fusion of the WBP11 and LGR5 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| WBP11-LGR5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| WBP11-LGR5-20-RERE | 20 (40 μL) | 200 μL |
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| WBP11-LGR5-20-REOR | 20 (40 μL) | 200 μL |
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| WBP11-LGR5-20-REGO | 20 (40 μL) | 200 μL |
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| WBP11-LGR5-20-REGR | 20 (40 μL) | 200 μL |
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| WBP11-LGR5-20-REAQ | 20 (40 μL) | 200 μL |
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| WBP11-LGR5-20-ORRE | 20 (40 μL) | 200 μL |
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| WBP11-LGR5-20-OROR | 20 (40 μL) | 200 μL |
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| WBP11-LGR5-20-ORGO | 20 (40 μL) | 200 μL |
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| WBP11-LGR5-20-ORAQ | 20 (40 μL) | 200 μL |
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| WBP11-LGR5-20-GORE | 20 (40 μL) | 200 μL |
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| WBP11-LGR5-20-GOOR | 20 (40 μL) | 200 μL |
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| WBP11-LGR5-20-GOGO | 20 (40 μL) | 200 μL |
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| WBP11-LGR5-20-GOGR | 20 (40 μL) | 200 μL |
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| WBP11-LGR5-20-GOAQ | 20 (40 μL) | 200 μL |
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| WBP11-LGR5-20-GRRE | 20 (40 μL) | 200 μL |
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| WBP11-LGR5-20-GROR | 20 (40 μL) | 200 μL |
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| WBP11-LGR5-20-GRGO | 20 (40 μL) | 200 μL |
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| WBP11-LGR5-20-GRGR | 20 (40 μL) | 200 μL |
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| WBP11-LGR5-20-GRAQ | 20 (40 μL) | 200 μL |
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| WBP11-LGR5-20-AQRE | 20 (40 μL) | 200 μL |
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| WBP11-LGR5-20-AQOR | 20 (40 μL) | 200 μL |
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| WBP11-LGR5-20-AQGO | 20 (40 μL) | 200 μL |
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| WBP11-LGR5-20-AQGR | 20 (40 μL) | 200 μL |
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| WBP11-LGR5-20-AQAQ | 20 (40 μL) | 200 μL |
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LGR5 Gene Summary
The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Gene Name: Leucine Rich Repeat Containing G Protein-coupled Receptor 5
Chromosome: CHR12: 71833812 -71978621
Locus: 12q21.1
WBP11 Gene Summary
This gene encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. This protein has 95% amino acid sequence identity to the mouse Wbp11 protein. It contains two proline-rich regions that bind to the WW domain of Npw38, a nuclear protein, and thus this protein is also called Npw38-binding protein NpwBP. The Npw38-NpwBP complex may function as a component of an mRNA factory in the nucleus. [provided by RefSeq, Jul 2008]
Gene Name: WW Domain Binding Protein 11
Chromosome: CHR12: 14939411 -14956401
Locus: 12p12.3
Gene Diseases
The WBP11 LGR5 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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