WASF3-CDK8 Fusion FISH Probe
The WASF3-CDK8 Fusion FISH Probe is used to confirm a fusion of the WASF3 and CDK8 genes. The fusion of the WASF3 and CDK8 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| WASF3-CDK8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| WASF3-CDK8-20-RERE | 20 (40 μL) | 200 μL |
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| WASF3-CDK8-20-REOR | 20 (40 μL) | 200 μL |
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| WASF3-CDK8-20-REGO | 20 (40 μL) | 200 μL |
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| WASF3-CDK8-20-REGR | 20 (40 μL) | 200 μL |
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| WASF3-CDK8-20-REAQ | 20 (40 μL) | 200 μL |
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| WASF3-CDK8-20-ORRE | 20 (40 μL) | 200 μL |
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| WASF3-CDK8-20-OROR | 20 (40 μL) | 200 μL |
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| WASF3-CDK8-20-ORGO | 20 (40 μL) | 200 μL |
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| WASF3-CDK8-20-ORAQ | 20 (40 μL) | 200 μL |
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| WASF3-CDK8-20-GORE | 20 (40 μL) | 200 μL |
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| WASF3-CDK8-20-GOOR | 20 (40 μL) | 200 μL |
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| WASF3-CDK8-20-GOGO | 20 (40 μL) | 200 μL |
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| WASF3-CDK8-20-GOGR | 20 (40 μL) | 200 μL |
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| WASF3-CDK8-20-GOAQ | 20 (40 μL) | 200 μL |
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| WASF3-CDK8-20-GRRE | 20 (40 μL) | 200 μL |
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| WASF3-CDK8-20-GROR | 20 (40 μL) | 200 μL |
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| WASF3-CDK8-20-GRGO | 20 (40 μL) | 200 μL |
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| WASF3-CDK8-20-GRGR | 20 (40 μL) | 200 μL |
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| WASF3-CDK8-20-GRAQ | 20 (40 μL) | 200 μL |
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| WASF3-CDK8-20-AQRE | 20 (40 μL) | 200 μL |
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| WASF3-CDK8-20-AQOR | 20 (40 μL) | 200 μL |
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| WASF3-CDK8-20-AQGO | 20 (40 μL) | 200 μL |
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| WASF3-CDK8-20-AQGR | 20 (40 μL) | 200 μL |
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| WASF3-CDK8-20-AQAQ | 20 (40 μL) | 200 μL |
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CDK8 Gene Summary
This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Gene Name: Cyclin Dependent Kinase 8
Chromosome: CHR13: 26828755 -26978569
Locus: 13q12.13
WASF3 Gene Summary
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. A pseudogene of this gene have been defined on chromosome 6. Alternative splicing results in multiple transcript variants [provided by RefSeq, May 2014]
Gene Name: WAS Protein Family Member 3
Chromosome: CHR13: 27131839 -27263082
Locus: 13q12.13
Gene Diseases
The WASF3 CDK8 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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