WASF2-FGR Fusion FISH Probe
The WASF2-FGR Fusion FISH Probe is used to confirm a fusion of the WASF2 and FGR genes. The fusion of the WASF2 and FGR genes has been associated with Lung Squamous Cell Carcinoma, Skin Cutaneous Melanoma, Esophageal Carcinoma, and Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| WASF2-FGR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| WASF2-FGR-20-RERE | 20 (40 μL) | 200 μL |
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| WASF2-FGR-20-REOR | 20 (40 μL) | 200 μL |
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| WASF2-FGR-20-REGO | 20 (40 μL) | 200 μL |
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| WASF2-FGR-20-REGR | 20 (40 μL) | 200 μL |
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| WASF2-FGR-20-REAQ | 20 (40 μL) | 200 μL |
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| WASF2-FGR-20-ORRE | 20 (40 μL) | 200 μL |
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| WASF2-FGR-20-OROR | 20 (40 μL) | 200 μL |
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| WASF2-FGR-20-ORGO | 20 (40 μL) | 200 μL |
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| WASF2-FGR-20-ORAQ | 20 (40 μL) | 200 μL |
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| WASF2-FGR-20-GORE | 20 (40 μL) | 200 μL |
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| WASF2-FGR-20-GOOR | 20 (40 μL) | 200 μL |
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| WASF2-FGR-20-GOGO | 20 (40 μL) | 200 μL |
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| WASF2-FGR-20-GOGR | 20 (40 μL) | 200 μL |
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| WASF2-FGR-20-GOAQ | 20 (40 μL) | 200 μL |
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| WASF2-FGR-20-GRRE | 20 (40 μL) | 200 μL |
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| WASF2-FGR-20-GROR | 20 (40 μL) | 200 μL |
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| WASF2-FGR-20-GRGO | 20 (40 μL) | 200 μL |
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| WASF2-FGR-20-GRGR | 20 (40 μL) | 200 μL |
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| WASF2-FGR-20-GRAQ | 20 (40 μL) | 200 μL |
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| WASF2-FGR-20-AQRE | 20 (40 μL) | 200 μL |
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| WASF2-FGR-20-AQOR | 20 (40 μL) | 200 μL |
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| WASF2-FGR-20-AQGO | 20 (40 μL) | 200 μL |
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| WASF2-FGR-20-AQGR | 20 (40 μL) | 200 μL |
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| WASF2-FGR-20-AQAQ | 20 (40 μL) | 200 μL |
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FGR Gene Summary
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Gene Name: FGR Proto-oncogene, Src Family Tyrosine Kinase
Chromosome: CHR1: 27938800 -27961727
Locus: 1p35.3
WASF2 Gene Summary
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Gene Name: WAS Protein Family Member 2
Chromosome: CHR1: 27730733 -27816678
Locus: 1p36.11
Gene Diseases
The WASF2 FGR Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
| Skin Cutaneous Melanoma |
| Esophageal Carcinoma |
| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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