WARS2-PHGDH Fusion FISH Probe
The WARS2-PHGDH Fusion FISH Probe is used to confirm a fusion of the WARS2 and PHGDH genes. The fusion of the WARS2 and PHGDH genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| WARS2-PHGDH-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| WARS2-PHGDH-20-RERE | 20 (40 μL) | 200 μL |
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| WARS2-PHGDH-20-REOR | 20 (40 μL) | 200 μL |
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| WARS2-PHGDH-20-REGO | 20 (40 μL) | 200 μL |
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| WARS2-PHGDH-20-REGR | 20 (40 μL) | 200 μL |
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| WARS2-PHGDH-20-REAQ | 20 (40 μL) | 200 μL |
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| WARS2-PHGDH-20-ORRE | 20 (40 μL) | 200 μL |
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| WARS2-PHGDH-20-OROR | 20 (40 μL) | 200 μL |
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| WARS2-PHGDH-20-ORGO | 20 (40 μL) | 200 μL |
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| WARS2-PHGDH-20-ORAQ | 20 (40 μL) | 200 μL |
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| WARS2-PHGDH-20-GORE | 20 (40 μL) | 200 μL |
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| WARS2-PHGDH-20-GOOR | 20 (40 μL) | 200 μL |
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| WARS2-PHGDH-20-GOGO | 20 (40 μL) | 200 μL |
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| WARS2-PHGDH-20-GOGR | 20 (40 μL) | 200 μL |
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| WARS2-PHGDH-20-GOAQ | 20 (40 μL) | 200 μL |
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| WARS2-PHGDH-20-GRRE | 20 (40 μL) | 200 μL |
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| WARS2-PHGDH-20-GROR | 20 (40 μL) | 200 μL |
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| WARS2-PHGDH-20-GRGO | 20 (40 μL) | 200 μL |
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| WARS2-PHGDH-20-GRGR | 20 (40 μL) | 200 μL |
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| WARS2-PHGDH-20-GRAQ | 20 (40 μL) | 200 μL |
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| WARS2-PHGDH-20-AQRE | 20 (40 μL) | 200 μL |
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| WARS2-PHGDH-20-AQOR | 20 (40 μL) | 200 μL |
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| WARS2-PHGDH-20-AQGO | 20 (40 μL) | 200 μL |
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| WARS2-PHGDH-20-AQGR | 20 (40 μL) | 200 μL |
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| WARS2-PHGDH-20-AQAQ | 20 (40 μL) | 200 μL |
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WARS2 Gene Summary
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Tryptophanyl TRNA Synthetase 2, Mitochondrial
Chromosome: CHR1: 119573838 -119683295
Locus: 1p12
PHGDH Gene Summary
This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011]
Gene Name: Phosphoglycerate Dehydrogenase
Chromosome: CHR1: 120254418 -120286849
Locus: 1p12
Gene Diseases
The WARS2 PHGDH Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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