VWA2-IDE Fusion FISH Probe
The VWA2-IDE Fusion FISH Probe is used to confirm a fusion of the VWA2 and IDE genes. The fusion of the VWA2 and IDE genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| VWA2-IDE-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| VWA2-IDE-20-RERE | 20 (40 μL) | 200 μL |
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| VWA2-IDE-20-REOR | 20 (40 μL) | 200 μL |
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| VWA2-IDE-20-REGO | 20 (40 μL) | 200 μL |
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| VWA2-IDE-20-REGR | 20 (40 μL) | 200 μL |
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| VWA2-IDE-20-REAQ | 20 (40 μL) | 200 μL |
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| VWA2-IDE-20-ORRE | 20 (40 μL) | 200 μL |
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| VWA2-IDE-20-OROR | 20 (40 μL) | 200 μL |
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| VWA2-IDE-20-ORGO | 20 (40 μL) | 200 μL |
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| VWA2-IDE-20-ORAQ | 20 (40 μL) | 200 μL |
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| VWA2-IDE-20-GORE | 20 (40 μL) | 200 μL |
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| VWA2-IDE-20-GOOR | 20 (40 μL) | 200 μL |
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| VWA2-IDE-20-GOGO | 20 (40 μL) | 200 μL |
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| VWA2-IDE-20-GOGR | 20 (40 μL) | 200 μL |
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| VWA2-IDE-20-GOAQ | 20 (40 μL) | 200 μL |
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| VWA2-IDE-20-GRRE | 20 (40 μL) | 200 μL |
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| VWA2-IDE-20-GROR | 20 (40 μL) | 200 μL |
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| VWA2-IDE-20-GRGO | 20 (40 μL) | 200 μL |
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| VWA2-IDE-20-GRGR | 20 (40 μL) | 200 μL |
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| VWA2-IDE-20-GRAQ | 20 (40 μL) | 200 μL |
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| VWA2-IDE-20-AQRE | 20 (40 μL) | 200 μL |
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| VWA2-IDE-20-AQOR | 20 (40 μL) | 200 μL |
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| VWA2-IDE-20-AQGO | 20 (40 μL) | 200 μL |
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| VWA2-IDE-20-AQGR | 20 (40 μL) | 200 μL |
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| VWA2-IDE-20-AQAQ | 20 (40 μL) | 200 μL |
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IDE Gene Summary
This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]
Gene Name: Insulin Degrading Enzyme
Chromosome: CHR10: 94211440 -94333852
Locus: 10q23.33
VWA2 Gene Summary
This gene encodes a member of the von Willebrand factor A-like domain protein superfamily. The encoded protein is localized to the extracellular matrix and may serve as a structural component in basement membranes or in anchoring structures on scaffolds of collagen VII or fibrillin. This gene has been linked to type 1A diabetes and is a candidate serological marker for colon cancer. [provided by RefSeq, Jan 2013]
Gene Name: Von Willebrand Factor A Domain Containing 2
Chromosome: CHR10: 115999017 -116049751
Locus: 10q25.3
Gene Diseases
The VWA2 IDE Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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