VTI1A-HDAC1 Fusion FISH Probe
The VTI1A-HDAC1 Fusion FISH Probe is used to confirm a fusion of the VTI1A and HDAC1 genes. The fusion of the VTI1A and HDAC1 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| VTI1A-HDAC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| VTI1A-HDAC1-20-RERE | 20 (40 μL) | 200 μL |
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| VTI1A-HDAC1-20-REOR | 20 (40 μL) | 200 μL |
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| VTI1A-HDAC1-20-REGO | 20 (40 μL) | 200 μL |
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| VTI1A-HDAC1-20-REGR | 20 (40 μL) | 200 μL |
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| VTI1A-HDAC1-20-REAQ | 20 (40 μL) | 200 μL |
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| VTI1A-HDAC1-20-ORRE | 20 (40 μL) | 200 μL |
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| VTI1A-HDAC1-20-OROR | 20 (40 μL) | 200 μL |
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| VTI1A-HDAC1-20-ORGO | 20 (40 μL) | 200 μL |
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| VTI1A-HDAC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| VTI1A-HDAC1-20-GORE | 20 (40 μL) | 200 μL |
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| VTI1A-HDAC1-20-GOOR | 20 (40 μL) | 200 μL |
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| VTI1A-HDAC1-20-GOGO | 20 (40 μL) | 200 μL |
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| VTI1A-HDAC1-20-GOGR | 20 (40 μL) | 200 μL |
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| VTI1A-HDAC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| VTI1A-HDAC1-20-GRRE | 20 (40 μL) | 200 μL |
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| VTI1A-HDAC1-20-GROR | 20 (40 μL) | 200 μL |
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| VTI1A-HDAC1-20-GRGO | 20 (40 μL) | 200 μL |
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| VTI1A-HDAC1-20-GRGR | 20 (40 μL) | 200 μL |
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| VTI1A-HDAC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| VTI1A-HDAC1-20-AQRE | 20 (40 μL) | 200 μL |
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| VTI1A-HDAC1-20-AQOR | 20 (40 μL) | 200 μL |
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| VTI1A-HDAC1-20-AQGO | 20 (40 μL) | 200 μL |
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| VTI1A-HDAC1-20-AQGR | 20 (40 μL) | 200 μL |
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| VTI1A-HDAC1-20-AQAQ | 20 (40 μL) | 200 μL |
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HDAC1 Gene Summary
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]
Gene Name: Histone Deacetylase 1
Chromosome: CHR1: 32757707 -32799224
Locus: 1p35.2-p35.1
VTI1A Gene Summary
The protein encoded by this gene is a member of the family of soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNAREs) that function in intracellular trafficking. This family member is involved in vesicular transport between endosomes and the trans-Golgi network. It is a vesicle-associated SNARE (v-SNARE) that interacts with target membrane SNAREs (t-SNAREs). Polymorphisms in this gene have been associated with binocular function, and also with susceptibility to colorectal and lung cancers. A recurrent rearrangement has been found between this gene and the transcription factor 7-like 2 (TCF7L2) gene in colorectal cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Gene Name: Vesicle Transport Through Interaction With T-SNAREs 1A
Chromosome: CHR10: 114206755 -114578504
Locus: 10q25.2
Gene Diseases
The VTI1A HDAC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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