VTI1A-ACSL5 Fusion FISH Probe
The VTI1A-ACSL5 Fusion FISH Probe is used to confirm a fusion of the VTI1A and ACSL5 genes. The fusion of the VTI1A and ACSL5 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| VTI1A-ACSL5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| VTI1A-ACSL5-20-RERE | 20 (40 μL) | 200 μL |
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| VTI1A-ACSL5-20-REOR | 20 (40 μL) | 200 μL |
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| VTI1A-ACSL5-20-REGO | 20 (40 μL) | 200 μL |
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| VTI1A-ACSL5-20-REGR | 20 (40 μL) | 200 μL |
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| VTI1A-ACSL5-20-REAQ | 20 (40 μL) | 200 μL |
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| VTI1A-ACSL5-20-ORRE | 20 (40 μL) | 200 μL |
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| VTI1A-ACSL5-20-OROR | 20 (40 μL) | 200 μL |
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| VTI1A-ACSL5-20-ORGO | 20 (40 μL) | 200 μL |
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| VTI1A-ACSL5-20-ORAQ | 20 (40 μL) | 200 μL |
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| VTI1A-ACSL5-20-GORE | 20 (40 μL) | 200 μL |
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| VTI1A-ACSL5-20-GOOR | 20 (40 μL) | 200 μL |
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| VTI1A-ACSL5-20-GOGO | 20 (40 μL) | 200 μL |
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| VTI1A-ACSL5-20-GOGR | 20 (40 μL) | 200 μL |
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| VTI1A-ACSL5-20-GOAQ | 20 (40 μL) | 200 μL |
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| VTI1A-ACSL5-20-GRRE | 20 (40 μL) | 200 μL |
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| VTI1A-ACSL5-20-GROR | 20 (40 μL) | 200 μL |
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| VTI1A-ACSL5-20-GRGO | 20 (40 μL) | 200 μL |
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| VTI1A-ACSL5-20-GRGR | 20 (40 μL) | 200 μL |
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| VTI1A-ACSL5-20-GRAQ | 20 (40 μL) | 200 μL |
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| VTI1A-ACSL5-20-AQRE | 20 (40 μL) | 200 μL |
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| VTI1A-ACSL5-20-AQOR | 20 (40 μL) | 200 μL |
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| VTI1A-ACSL5-20-AQGO | 20 (40 μL) | 200 μL |
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| VTI1A-ACSL5-20-AQGR | 20 (40 μL) | 200 μL |
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| VTI1A-ACSL5-20-AQAQ | 20 (40 μL) | 200 μL |
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ACSL5 Gene Summary
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Acyl-CoA Synthetase Long Chain Family Member 5
Chromosome: CHR10: 114133915 -114188138
Locus: 10q25.2
VTI1A Gene Summary
The protein encoded by this gene is a member of the family of soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNAREs) that function in intracellular trafficking. This family member is involved in vesicular transport between endosomes and the trans-Golgi network. It is a vesicle-associated SNARE (v-SNARE) that interacts with target membrane SNAREs (t-SNAREs). Polymorphisms in this gene have been associated with binocular function, and also with susceptibility to colorectal and lung cancers. A recurrent rearrangement has been found between this gene and the transcription factor 7-like 2 (TCF7L2) gene in colorectal cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Gene Name: Vesicle Transport Through Interaction With T-SNAREs 1A
Chromosome: CHR10: 114206755 -114578504
Locus: 10q25.2
Gene Diseases
The VTI1A ACSL5 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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