VRK1-PAPOLA Fusion FISH Probe
The VRK1-PAPOLA Fusion FISH Probe is used to confirm a fusion of the VRK1 and PAPOLA genes. The fusion of the VRK1 and PAPOLA genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| VRK1-PAPOLA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| VRK1-PAPOLA-20-RERE | 20 (40 μL) | 200 μL |
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| VRK1-PAPOLA-20-REOR | 20 (40 μL) | 200 μL |
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| VRK1-PAPOLA-20-REGO | 20 (40 μL) | 200 μL |
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| VRK1-PAPOLA-20-REGR | 20 (40 μL) | 200 μL |
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| VRK1-PAPOLA-20-REAQ | 20 (40 μL) | 200 μL |
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| VRK1-PAPOLA-20-ORRE | 20 (40 μL) | 200 μL |
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| VRK1-PAPOLA-20-OROR | 20 (40 μL) | 200 μL |
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| VRK1-PAPOLA-20-ORGO | 20 (40 μL) | 200 μL |
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| VRK1-PAPOLA-20-ORAQ | 20 (40 μL) | 200 μL |
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| VRK1-PAPOLA-20-GORE | 20 (40 μL) | 200 μL |
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| VRK1-PAPOLA-20-GOOR | 20 (40 μL) | 200 μL |
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| VRK1-PAPOLA-20-GOGO | 20 (40 μL) | 200 μL |
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| VRK1-PAPOLA-20-GOGR | 20 (40 μL) | 200 μL |
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| VRK1-PAPOLA-20-GOAQ | 20 (40 μL) | 200 μL |
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| VRK1-PAPOLA-20-GRRE | 20 (40 μL) | 200 μL |
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| VRK1-PAPOLA-20-GROR | 20 (40 μL) | 200 μL |
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| VRK1-PAPOLA-20-GRGO | 20 (40 μL) | 200 μL |
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| VRK1-PAPOLA-20-GRGR | 20 (40 μL) | 200 μL |
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| VRK1-PAPOLA-20-GRAQ | 20 (40 μL) | 200 μL |
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| VRK1-PAPOLA-20-AQRE | 20 (40 μL) | 200 μL |
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| VRK1-PAPOLA-20-AQOR | 20 (40 μL) | 200 μL |
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| VRK1-PAPOLA-20-AQGO | 20 (40 μL) | 200 μL |
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| VRK1-PAPOLA-20-AQGR | 20 (40 μL) | 200 μL |
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| VRK1-PAPOLA-20-AQAQ | 20 (40 μL) | 200 μL |
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VRK1 Gene Summary
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008]
Gene Name: Vaccinia Related Kinase 1
Chromosome: CHR14: 97263683 -97347951
Locus: 14q32.2
PAPOLA Gene Summary
The protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3'-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Poly(A) Polymerase Alpha
Chromosome: CHR14: 96968719 -97033448
Locus: 14q32.2
Gene Diseases
The VRK1 PAPOLA Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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