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VPS72-RORC Fusion FISH Probe

The VPS72-RORC Fusion FISH Probe is used to confirm a fusion of the VPS72 and RORC genes. The fusion of the VPS72 and RORC genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
VPS72-RORC-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
VPS72-RORC-20-RERE 20 (40 μL) 200 μL
VPS72-RORC-20-REOR 20 (40 μL) 200 μL
VPS72-RORC-20-REGO 20 (40 μL) 200 μL
VPS72-RORC-20-REGR 20 (40 μL) 200 μL
VPS72-RORC-20-REAQ 20 (40 μL) 200 μL
VPS72-RORC-20-ORRE 20 (40 μL) 200 μL
VPS72-RORC-20-OROR 20 (40 μL) 200 μL
VPS72-RORC-20-ORGO 20 (40 μL) 200 μL
VPS72-RORC-20-ORAQ 20 (40 μL) 200 μL
VPS72-RORC-20-GORE 20 (40 μL) 200 μL
VPS72-RORC-20-GOOR 20 (40 μL) 200 μL
VPS72-RORC-20-GOGO 20 (40 μL) 200 μL
VPS72-RORC-20-GOGR 20 (40 μL) 200 μL
VPS72-RORC-20-GOAQ 20 (40 μL) 200 μL
VPS72-RORC-20-GRRE 20 (40 μL) 200 μL
VPS72-RORC-20-GROR 20 (40 μL) 200 μL
VPS72-RORC-20-GRGO 20 (40 μL) 200 μL
VPS72-RORC-20-GRGR 20 (40 μL) 200 μL
VPS72-RORC-20-GRAQ 20 (40 μL) 200 μL
VPS72-RORC-20-AQRE 20 (40 μL) 200 μL
VPS72-RORC-20-AQOR 20 (40 μL) 200 μL
VPS72-RORC-20-AQGO 20 (40 μL) 200 μL
VPS72-RORC-20-AQGR 20 (40 μL) 200 μL
VPS72-RORC-20-AQAQ 20 (40 μL) 200 μL

RORC Gene Summary

The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Name: RAR Related Orphan Receptor C

Chromosome: CHR1: 151778546 -151804348

Locus: 1q21.3

VPS72 Gene Summary

The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

Gene Name: Vacuolar Protein Sorting 72 Homolog

Chromosome: CHR1: 151148933 -151162640

Locus: 1q21.3

Gene Diseases

The VPS72 RORC Fusion has been associated with the following diseases:

Disease Name
Lung Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.