VPS72-RORC Fusion FISH Probe
The VPS72-RORC Fusion FISH Probe is used to confirm a fusion of the VPS72 and RORC genes. The fusion of the VPS72 and RORC genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| VPS72-RORC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| VPS72-RORC-20-RERE | 20 (40 μL) | 200 μL |
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| VPS72-RORC-20-REOR | 20 (40 μL) | 200 μL |
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| VPS72-RORC-20-REGO | 20 (40 μL) | 200 μL |
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| VPS72-RORC-20-REGR | 20 (40 μL) | 200 μL |
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| VPS72-RORC-20-REAQ | 20 (40 μL) | 200 μL |
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| VPS72-RORC-20-ORRE | 20 (40 μL) | 200 μL |
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| VPS72-RORC-20-OROR | 20 (40 μL) | 200 μL |
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| VPS72-RORC-20-ORGO | 20 (40 μL) | 200 μL |
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| VPS72-RORC-20-ORAQ | 20 (40 μL) | 200 μL |
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| VPS72-RORC-20-GORE | 20 (40 μL) | 200 μL |
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| VPS72-RORC-20-GOOR | 20 (40 μL) | 200 μL |
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| VPS72-RORC-20-GOGO | 20 (40 μL) | 200 μL |
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| VPS72-RORC-20-GOGR | 20 (40 μL) | 200 μL |
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| VPS72-RORC-20-GOAQ | 20 (40 μL) | 200 μL |
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| VPS72-RORC-20-GRRE | 20 (40 μL) | 200 μL |
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| VPS72-RORC-20-GROR | 20 (40 μL) | 200 μL |
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| VPS72-RORC-20-GRGO | 20 (40 μL) | 200 μL |
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| VPS72-RORC-20-GRGR | 20 (40 μL) | 200 μL |
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| VPS72-RORC-20-GRAQ | 20 (40 μL) | 200 μL |
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| VPS72-RORC-20-AQRE | 20 (40 μL) | 200 μL |
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| VPS72-RORC-20-AQOR | 20 (40 μL) | 200 μL |
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| VPS72-RORC-20-AQGO | 20 (40 μL) | 200 μL |
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| VPS72-RORC-20-AQGR | 20 (40 μL) | 200 μL |
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| VPS72-RORC-20-AQAQ | 20 (40 μL) | 200 μL |
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RORC Gene Summary
The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: RAR Related Orphan Receptor C
Chromosome: CHR1: 151778546 -151804348
Locus: 1q21.3
VPS72 Gene Summary
The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
Gene Name: Vacuolar Protein Sorting 72 Homolog
Chromosome: CHR1: 151148933 -151162640
Locus: 1q21.3
Gene Diseases
The VPS72 RORC Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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