VPS72-ROBO2 Fusion FISH Probe
The VPS72-ROBO2 Fusion FISH Probe is used to confirm a fusion of the VPS72 and ROBO2 genes. The fusion of the VPS72 and ROBO2 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| VPS72-ROBO2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| VPS72-ROBO2-20-RERE | 20 (40 μL) | 200 μL |
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| VPS72-ROBO2-20-REOR | 20 (40 μL) | 200 μL |
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| VPS72-ROBO2-20-REGO | 20 (40 μL) | 200 μL |
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| VPS72-ROBO2-20-REGR | 20 (40 μL) | 200 μL |
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| VPS72-ROBO2-20-REAQ | 20 (40 μL) | 200 μL |
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| VPS72-ROBO2-20-ORRE | 20 (40 μL) | 200 μL |
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| VPS72-ROBO2-20-OROR | 20 (40 μL) | 200 μL |
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| VPS72-ROBO2-20-ORGO | 20 (40 μL) | 200 μL |
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| VPS72-ROBO2-20-ORAQ | 20 (40 μL) | 200 μL |
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| VPS72-ROBO2-20-GORE | 20 (40 μL) | 200 μL |
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| VPS72-ROBO2-20-GOOR | 20 (40 μL) | 200 μL |
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| VPS72-ROBO2-20-GOGO | 20 (40 μL) | 200 μL |
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| VPS72-ROBO2-20-GOGR | 20 (40 μL) | 200 μL |
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| VPS72-ROBO2-20-GOAQ | 20 (40 μL) | 200 μL |
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| VPS72-ROBO2-20-GRRE | 20 (40 μL) | 200 μL |
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| VPS72-ROBO2-20-GROR | 20 (40 μL) | 200 μL |
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| VPS72-ROBO2-20-GRGO | 20 (40 μL) | 200 μL |
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| VPS72-ROBO2-20-GRGR | 20 (40 μL) | 200 μL |
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| VPS72-ROBO2-20-GRAQ | 20 (40 μL) | 200 μL |
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| VPS72-ROBO2-20-AQRE | 20 (40 μL) | 200 μL |
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| VPS72-ROBO2-20-AQOR | 20 (40 μL) | 200 μL |
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| VPS72-ROBO2-20-AQGO | 20 (40 μL) | 200 μL |
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| VPS72-ROBO2-20-AQGR | 20 (40 μL) | 200 μL |
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| VPS72-ROBO2-20-AQAQ | 20 (40 μL) | 200 μL |
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ROBO2 Gene Summary
The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Name: Roundabout Guidance Receptor 2
Chromosome: CHR3: 77089293 -77699114
Locus: 3p12.3
VPS72 Gene Summary
The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
Gene Name: Vacuolar Protein Sorting 72 Homolog
Chromosome: CHR1: 151148933 -151162640
Locus: 1q21.3
Gene Diseases
The VPS72 ROBO2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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