VPS52-TAPBP Fusion FISH Probe
The VPS52-TAPBP Fusion FISH Probe is used to confirm a fusion of the VPS52 and TAPBP genes. The fusion of the VPS52 and TAPBP genes has been associated with Testicular Germ Cell Tumors. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| VPS52-TAPBP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| VPS52-TAPBP-20-RERE | 20 (40 μL) | 200 μL |
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| VPS52-TAPBP-20-REOR | 20 (40 μL) | 200 μL |
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| VPS52-TAPBP-20-REGO | 20 (40 μL) | 200 μL |
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| VPS52-TAPBP-20-REGR | 20 (40 μL) | 200 μL |
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| VPS52-TAPBP-20-REAQ | 20 (40 μL) | 200 μL |
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| VPS52-TAPBP-20-ORRE | 20 (40 μL) | 200 μL |
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| VPS52-TAPBP-20-OROR | 20 (40 μL) | 200 μL |
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| VPS52-TAPBP-20-ORGO | 20 (40 μL) | 200 μL |
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| VPS52-TAPBP-20-ORAQ | 20 (40 μL) | 200 μL |
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| VPS52-TAPBP-20-GORE | 20 (40 μL) | 200 μL |
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| VPS52-TAPBP-20-GOOR | 20 (40 μL) | 200 μL |
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| VPS52-TAPBP-20-GOGO | 20 (40 μL) | 200 μL |
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| VPS52-TAPBP-20-GOGR | 20 (40 μL) | 200 μL |
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| VPS52-TAPBP-20-GOAQ | 20 (40 μL) | 200 μL |
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| VPS52-TAPBP-20-GRRE | 20 (40 μL) | 200 μL |
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| VPS52-TAPBP-20-GROR | 20 (40 μL) | 200 μL |
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| VPS52-TAPBP-20-GRGO | 20 (40 μL) | 200 μL |
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| VPS52-TAPBP-20-GRGR | 20 (40 μL) | 200 μL |
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| VPS52-TAPBP-20-GRAQ | 20 (40 μL) | 200 μL |
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| VPS52-TAPBP-20-AQRE | 20 (40 μL) | 200 μL |
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| VPS52-TAPBP-20-AQOR | 20 (40 μL) | 200 μL |
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| VPS52-TAPBP-20-AQGO | 20 (40 μL) | 200 μL |
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| VPS52-TAPBP-20-AQGR | 20 (40 μL) | 200 μL |
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| VPS52-TAPBP-20-AQAQ | 20 (40 μL) | 200 μL |
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VPS52 Gene Summary
This gene encodes a protein that is similar to the yeast suppressor of actin mutations 2 gene. The yeast protein forms a subunit of the tetrameric Golgi-associated retrograde protein complex that is involved in vesicle trafficking from from both early and late endosomes, back to the trans-Golgi network. This gene is located on chromosome 6 in a head-to-head orientation with the gene encoding ribosomal protein S18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Name: VPS52, GARP Complex Subunit
Chromosome: CHR6_qbl_hap6: 4450267 -4471898
Locus: 6p21.32
TAPBP Gene Summary
This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: TAP Binding Protein
Chromosome: CHR6_qbl_hap6: 4499711 -4514410
Locus: 6p21.32
Gene Diseases
The VPS52 TAPBP Fusion has been associated with the following diseases:
| Disease Name |
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| Testicular Germ Cell Tumors |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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