VPS29-HSPB8 Fusion FISH Probe
The VPS29-HSPB8 Fusion FISH Probe is used to confirm a fusion of the VPS29 and HSPB8 genes. The fusion of the VPS29 and HSPB8 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| VPS29-HSPB8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| VPS29-HSPB8-20-RERE | 20 (40 μL) | 200 μL |
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| VPS29-HSPB8-20-REOR | 20 (40 μL) | 200 μL |
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| VPS29-HSPB8-20-REGO | 20 (40 μL) | 200 μL |
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| VPS29-HSPB8-20-REGR | 20 (40 μL) | 200 μL |
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| VPS29-HSPB8-20-REAQ | 20 (40 μL) | 200 μL |
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| VPS29-HSPB8-20-ORRE | 20 (40 μL) | 200 μL |
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| VPS29-HSPB8-20-OROR | 20 (40 μL) | 200 μL |
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| VPS29-HSPB8-20-ORGO | 20 (40 μL) | 200 μL |
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| VPS29-HSPB8-20-ORAQ | 20 (40 μL) | 200 μL |
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| VPS29-HSPB8-20-GORE | 20 (40 μL) | 200 μL |
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| VPS29-HSPB8-20-GOOR | 20 (40 μL) | 200 μL |
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| VPS29-HSPB8-20-GOGO | 20 (40 μL) | 200 μL |
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| VPS29-HSPB8-20-GOGR | 20 (40 μL) | 200 μL |
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| VPS29-HSPB8-20-GOAQ | 20 (40 μL) | 200 μL |
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| VPS29-HSPB8-20-GRRE | 20 (40 μL) | 200 μL |
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| VPS29-HSPB8-20-GROR | 20 (40 μL) | 200 μL |
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| VPS29-HSPB8-20-GRGO | 20 (40 μL) | 200 μL |
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| VPS29-HSPB8-20-GRGR | 20 (40 μL) | 200 μL |
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| VPS29-HSPB8-20-GRAQ | 20 (40 μL) | 200 μL |
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| VPS29-HSPB8-20-AQRE | 20 (40 μL) | 200 μL |
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| VPS29-HSPB8-20-AQOR | 20 (40 μL) | 200 μL |
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| VPS29-HSPB8-20-AQGO | 20 (40 μL) | 200 μL |
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| VPS29-HSPB8-20-AQGR | 20 (40 μL) | 200 μL |
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| VPS29-HSPB8-20-AQAQ | 20 (40 μL) | 200 μL |
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HSPB8 Gene Summary
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]
Gene Name: Heat Shock Protein Family B (small) Member 8
Chromosome: CHR12: 119616594 -119632551
Locus: 12q24.23
VPS29 Gene Summary
This gene belongs to a group of vacuolar protein sorting (VPS) genes that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. The protein encoded by this gene is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. This VPS protein may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment. Alternative splice variants encoding different isoforms and representing non-protein coding transcripts have been found for this gene. [provided by RefSeq, Aug 2013]
Gene Name: VPS29, Retromer Complex Component
Chromosome: CHR12: 110929329 -110939916
Locus: 12q24.11
Gene Diseases
The VPS29 HSPB8 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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