VPS18-NTRK3 Fusion FISH Probe
The VPS18-NTRK3 Fusion FISH Probe is used to confirm a fusion of the VPS18 and NTRK3 genes. The fusion of the VPS18 and NTRK3 genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| VPS18-NTRK3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| VPS18-NTRK3-20-RERE | 20 (40 μL) | 200 μL |
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| VPS18-NTRK3-20-REOR | 20 (40 μL) | 200 μL |
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| VPS18-NTRK3-20-REGO | 20 (40 μL) | 200 μL |
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| VPS18-NTRK3-20-REGR | 20 (40 μL) | 200 μL |
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| VPS18-NTRK3-20-REAQ | 20 (40 μL) | 200 μL |
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| VPS18-NTRK3-20-ORRE | 20 (40 μL) | 200 μL |
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| VPS18-NTRK3-20-OROR | 20 (40 μL) | 200 μL |
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| VPS18-NTRK3-20-ORGO | 20 (40 μL) | 200 μL |
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| VPS18-NTRK3-20-ORAQ | 20 (40 μL) | 200 μL |
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| VPS18-NTRK3-20-GORE | 20 (40 μL) | 200 μL |
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| VPS18-NTRK3-20-GOOR | 20 (40 μL) | 200 μL |
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| VPS18-NTRK3-20-GOGO | 20 (40 μL) | 200 μL |
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| VPS18-NTRK3-20-GOGR | 20 (40 μL) | 200 μL |
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| VPS18-NTRK3-20-GOAQ | 20 (40 μL) | 200 μL |
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| VPS18-NTRK3-20-GRRE | 20 (40 μL) | 200 μL |
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| VPS18-NTRK3-20-GROR | 20 (40 μL) | 200 μL |
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| VPS18-NTRK3-20-GRGO | 20 (40 μL) | 200 μL |
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| VPS18-NTRK3-20-GRGR | 20 (40 μL) | 200 μL |
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| VPS18-NTRK3-20-GRAQ | 20 (40 μL) | 200 μL |
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| VPS18-NTRK3-20-AQRE | 20 (40 μL) | 200 μL |
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| VPS18-NTRK3-20-AQOR | 20 (40 μL) | 200 μL |
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| VPS18-NTRK3-20-AQGO | 20 (40 μL) | 200 μL |
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| VPS18-NTRK3-20-AQGR | 20 (40 μL) | 200 μL |
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| VPS18-NTRK3-20-AQAQ | 20 (40 μL) | 200 μL |
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NTRK3 Gene Summary
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Gene Name: Neurotrophic Receptor Tyrosine Kinase 3
Chromosome: CHR15: 88419987 -88799962
Locus: 15q25.3
VPS18 Gene Summary
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. [provided by RefSeq, Jul 2008]
Gene Name: VPS18, CORVET/HOPS Core Subunit
Chromosome: CHR15: 41186627 -41196173
Locus: 15q15.1
Gene Diseases
The VPS18 NTRK3 Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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