VPS13D-TNFRSF1B Fusion FISH Probe
The VPS13D-TNFRSF1B Fusion FISH Probe is used to confirm a fusion of the VPS13D and TNFRSF1B genes. The fusion of the VPS13D and TNFRSF1B genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| VPS13D-TNFRSF1B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| VPS13D-TNFRSF1B-20-RERE | 20 (40 μL) | 200 μL |
|
|
| VPS13D-TNFRSF1B-20-REOR | 20 (40 μL) | 200 μL |
|
|
| VPS13D-TNFRSF1B-20-REGO | 20 (40 μL) | 200 μL |
|
|
| VPS13D-TNFRSF1B-20-REGR | 20 (40 μL) | 200 μL |
|
|
| VPS13D-TNFRSF1B-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| VPS13D-TNFRSF1B-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| VPS13D-TNFRSF1B-20-OROR | 20 (40 μL) | 200 μL |
|
|
| VPS13D-TNFRSF1B-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| VPS13D-TNFRSF1B-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| VPS13D-TNFRSF1B-20-GORE | 20 (40 μL) | 200 μL |
|
|
| VPS13D-TNFRSF1B-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| VPS13D-TNFRSF1B-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| VPS13D-TNFRSF1B-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| VPS13D-TNFRSF1B-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| VPS13D-TNFRSF1B-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| VPS13D-TNFRSF1B-20-GROR | 20 (40 μL) | 200 μL |
|
|
| VPS13D-TNFRSF1B-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| VPS13D-TNFRSF1B-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| VPS13D-TNFRSF1B-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| VPS13D-TNFRSF1B-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| VPS13D-TNFRSF1B-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| VPS13D-TNFRSF1B-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| VPS13D-TNFRSF1B-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| VPS13D-TNFRSF1B-20-AQAQ | 20 (40 μL) | 200 μL |
|
TNFRSF1B Gene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
Gene Name: TNF Receptor Superfamily Member 1B
Chromosome: CHR1: 12227059 -12269277
Locus: 1p36.22
VPS13D Gene Summary
This gene encodes a protein belonging to the vacuolar-protein-sorting-13 gene family. In yeast, vacuolar-protein-sorting-13 proteins are involved in trafficking of membrane proteins between the trans-Golgi network and the prevacuolar compartment. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Vacuolar Protein Sorting 13 Homolog D
Chromosome: CHR1: 12290112 -12572098
Locus: 1p36.22-p36.21
Gene Diseases
The VPS13D TNFRSF1B Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|