VPS13B-SGCZ Fusion FISH Probe
The VPS13B-SGCZ Fusion FISH Probe is used to confirm a fusion of the VPS13B and SGCZ genes. The fusion of the VPS13B and SGCZ genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| VPS13B-SGCZ-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| VPS13B-SGCZ-20-RERE | 20 (40 μL) | 200 μL |
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| VPS13B-SGCZ-20-REOR | 20 (40 μL) | 200 μL |
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| VPS13B-SGCZ-20-REGO | 20 (40 μL) | 200 μL |
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| VPS13B-SGCZ-20-REGR | 20 (40 μL) | 200 μL |
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| VPS13B-SGCZ-20-REAQ | 20 (40 μL) | 200 μL |
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| VPS13B-SGCZ-20-ORRE | 20 (40 μL) | 200 μL |
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| VPS13B-SGCZ-20-OROR | 20 (40 μL) | 200 μL |
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| VPS13B-SGCZ-20-ORGO | 20 (40 μL) | 200 μL |
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| VPS13B-SGCZ-20-ORAQ | 20 (40 μL) | 200 μL |
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| VPS13B-SGCZ-20-GORE | 20 (40 μL) | 200 μL |
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| VPS13B-SGCZ-20-GOOR | 20 (40 μL) | 200 μL |
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| VPS13B-SGCZ-20-GOGO | 20 (40 μL) | 200 μL |
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| VPS13B-SGCZ-20-GOGR | 20 (40 μL) | 200 μL |
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| VPS13B-SGCZ-20-GOAQ | 20 (40 μL) | 200 μL |
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| VPS13B-SGCZ-20-GRRE | 20 (40 μL) | 200 μL |
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| VPS13B-SGCZ-20-GROR | 20 (40 μL) | 200 μL |
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| VPS13B-SGCZ-20-GRGO | 20 (40 μL) | 200 μL |
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| VPS13B-SGCZ-20-GRGR | 20 (40 μL) | 200 μL |
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| VPS13B-SGCZ-20-GRAQ | 20 (40 μL) | 200 μL |
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| VPS13B-SGCZ-20-AQRE | 20 (40 μL) | 200 μL |
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| VPS13B-SGCZ-20-AQOR | 20 (40 μL) | 200 μL |
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| VPS13B-SGCZ-20-AQGO | 20 (40 μL) | 200 μL |
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| VPS13B-SGCZ-20-AQGR | 20 (40 μL) | 200 μL |
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| VPS13B-SGCZ-20-AQAQ | 20 (40 μL) | 200 μL |
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SGCZ Gene Summary
The zeta-sarcoglycan gene measures over 465 kb and localizes to 8p22. This protein is part of the sarcoglycan complex, a group of 6 proteins. The sarcoglycans are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a carboxyl-terminal cluster with several conserved cysteine residues. The sarcoglycan complex is part of the dystrophin-associated glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extra-cellular matrix. [provided by RefSeq, Jul 2008]
Gene Name: Sarcoglycan Zeta
Chromosome: CHR8: 13947372 -15095792
Locus: 8p22
VPS13B Gene Summary
This gene encodes a potential transmembrane protein that may function in vesicle-mediated transport and sorting of proteins within the cell. This protein may play a role in the development and the function of the eye, hematological system, and central nervous system. Mutations in this gene have been associated with Cohen syndrome. Multiple splice variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Vacuolar Protein Sorting 13 Homolog B
Chromosome: CHR8: 100025493 -100889808
Locus: 8q22.2
Gene Diseases
The VPS13B SGCZ Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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