VPS13B-GMDS Fusion FISH Probe
The VPS13B-GMDS Fusion FISH Probe is used to confirm a fusion of the VPS13B and GMDS genes. The fusion of the VPS13B and GMDS genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| VPS13B-GMDS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| VPS13B-GMDS-20-RERE | 20 (40 μL) | 200 μL |
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| VPS13B-GMDS-20-REOR | 20 (40 μL) | 200 μL |
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| VPS13B-GMDS-20-REGO | 20 (40 μL) | 200 μL |
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| VPS13B-GMDS-20-REGR | 20 (40 μL) | 200 μL |
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| VPS13B-GMDS-20-REAQ | 20 (40 μL) | 200 μL |
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| VPS13B-GMDS-20-ORRE | 20 (40 μL) | 200 μL |
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| VPS13B-GMDS-20-OROR | 20 (40 μL) | 200 μL |
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| VPS13B-GMDS-20-ORGO | 20 (40 μL) | 200 μL |
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| VPS13B-GMDS-20-ORAQ | 20 (40 μL) | 200 μL |
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| VPS13B-GMDS-20-GORE | 20 (40 μL) | 200 μL |
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| VPS13B-GMDS-20-GOOR | 20 (40 μL) | 200 μL |
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| VPS13B-GMDS-20-GOGO | 20 (40 μL) | 200 μL |
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| VPS13B-GMDS-20-GOGR | 20 (40 μL) | 200 μL |
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| VPS13B-GMDS-20-GOAQ | 20 (40 μL) | 200 μL |
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| VPS13B-GMDS-20-GRRE | 20 (40 μL) | 200 μL |
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| VPS13B-GMDS-20-GROR | 20 (40 μL) | 200 μL |
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| VPS13B-GMDS-20-GRGO | 20 (40 μL) | 200 μL |
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| VPS13B-GMDS-20-GRGR | 20 (40 μL) | 200 μL |
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| VPS13B-GMDS-20-GRAQ | 20 (40 μL) | 200 μL |
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| VPS13B-GMDS-20-AQRE | 20 (40 μL) | 200 μL |
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| VPS13B-GMDS-20-AQOR | 20 (40 μL) | 200 μL |
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| VPS13B-GMDS-20-AQGO | 20 (40 μL) | 200 μL |
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| VPS13B-GMDS-20-AQGR | 20 (40 μL) | 200 μL |
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| VPS13B-GMDS-20-AQAQ | 20 (40 μL) | 200 μL |
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GMDS Gene Summary
GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]
Gene Name: GDP-mannose 4,6-dehydratase
Chromosome: CHR6: 1624040 -2245846
Locus: 6p25.3
VPS13B Gene Summary
This gene encodes a potential transmembrane protein that may function in vesicle-mediated transport and sorting of proteins within the cell. This protein may play a role in the development and the function of the eye, hematological system, and central nervous system. Mutations in this gene have been associated with Cohen syndrome. Multiple splice variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Vacuolar Protein Sorting 13 Homolog B
Chromosome: CHR8: 100025493 -100889808
Locus: 8q22.2
Gene Diseases
The VPS13B GMDS Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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