VKORC1L1-ACHE Fusion FISH Probe
The VKORC1L1-ACHE Fusion FISH Probe is used to confirm a fusion of the VKORC1L1 and ACHE genes. The fusion of the VKORC1L1 and ACHE genes has been associated with Rectum Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| VKORC1L1-ACHE-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| VKORC1L1-ACHE-20-RERE | 20 (40 μL) | 200 μL |
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| VKORC1L1-ACHE-20-REOR | 20 (40 μL) | 200 μL |
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| VKORC1L1-ACHE-20-REGO | 20 (40 μL) | 200 μL |
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| VKORC1L1-ACHE-20-REGR | 20 (40 μL) | 200 μL |
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| VKORC1L1-ACHE-20-REAQ | 20 (40 μL) | 200 μL |
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| VKORC1L1-ACHE-20-ORRE | 20 (40 μL) | 200 μL |
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| VKORC1L1-ACHE-20-OROR | 20 (40 μL) | 200 μL |
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| VKORC1L1-ACHE-20-ORGO | 20 (40 μL) | 200 μL |
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| VKORC1L1-ACHE-20-ORAQ | 20 (40 μL) | 200 μL |
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| VKORC1L1-ACHE-20-GORE | 20 (40 μL) | 200 μL |
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| VKORC1L1-ACHE-20-GOOR | 20 (40 μL) | 200 μL |
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| VKORC1L1-ACHE-20-GOGO | 20 (40 μL) | 200 μL |
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| VKORC1L1-ACHE-20-GOGR | 20 (40 μL) | 200 μL |
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| VKORC1L1-ACHE-20-GOAQ | 20 (40 μL) | 200 μL |
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| VKORC1L1-ACHE-20-GRRE | 20 (40 μL) | 200 μL |
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| VKORC1L1-ACHE-20-GROR | 20 (40 μL) | 200 μL |
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| VKORC1L1-ACHE-20-GRGO | 20 (40 μL) | 200 μL |
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| VKORC1L1-ACHE-20-GRGR | 20 (40 μL) | 200 μL |
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| VKORC1L1-ACHE-20-GRAQ | 20 (40 μL) | 200 μL |
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| VKORC1L1-ACHE-20-AQRE | 20 (40 μL) | 200 μL |
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| VKORC1L1-ACHE-20-AQOR | 20 (40 μL) | 200 μL |
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| VKORC1L1-ACHE-20-AQGO | 20 (40 μL) | 200 μL |
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| VKORC1L1-ACHE-20-AQGR | 20 (40 μL) | 200 μL |
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| VKORC1L1-ACHE-20-AQAQ | 20 (40 μL) | 200 μL |
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ACHE Gene Summary
Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008]
Gene Name: Acetylcholinesterase (Cartwright Blood Group)
Chromosome: CHR7: 100487614 -100493541
Locus: 7q22.1
VKORC1L1 Gene Summary
This gene encodes an enzyme important in the vitamin K cycle, which is involved in the carboxylation of glutamate residues present in vitamin K-dependent proteins. The encoded enzyme catalyzes the de-epoxidation of vitamin K 2,3-epoxide. Oxidative stress may upregulate expression of this gene and the encoded protein may protect cells and membrane proteins form oxidative damage. This gene and a related gene (Gene ID: 79001) may have arisen by gene duplication of an ancestral gene. [provided by RefSeq, Oct 2016]
Gene Name: Vitamin K Epoxide Reductase Complex Subunit 1 Like 1
Chromosome: CHR7: 65338256 -65419800
Locus: 7q11.21
Gene Diseases
The VKORC1L1 ACHE Fusion has been associated with the following diseases:
| Disease Name |
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| Rectum Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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