VIM-PTPRC Fusion FISH Probe
The VIM-PTPRC Fusion FISH Probe is used to confirm a fusion of the VIM and PTPRC genes. The fusion of the VIM and PTPRC genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| VIM-PTPRC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| VIM-PTPRC-20-RERE | 20 (40 μL) | 200 μL |
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| VIM-PTPRC-20-REOR | 20 (40 μL) | 200 μL |
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| VIM-PTPRC-20-REGO | 20 (40 μL) | 200 μL |
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| VIM-PTPRC-20-REGR | 20 (40 μL) | 200 μL |
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| VIM-PTPRC-20-REAQ | 20 (40 μL) | 200 μL |
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| VIM-PTPRC-20-ORRE | 20 (40 μL) | 200 μL |
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| VIM-PTPRC-20-OROR | 20 (40 μL) | 200 μL |
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| VIM-PTPRC-20-ORGO | 20 (40 μL) | 200 μL |
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| VIM-PTPRC-20-ORAQ | 20 (40 μL) | 200 μL |
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| VIM-PTPRC-20-GORE | 20 (40 μL) | 200 μL |
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| VIM-PTPRC-20-GOOR | 20 (40 μL) | 200 μL |
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| VIM-PTPRC-20-GOGO | 20 (40 μL) | 200 μL |
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| VIM-PTPRC-20-GOGR | 20 (40 μL) | 200 μL |
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| VIM-PTPRC-20-GOAQ | 20 (40 μL) | 200 μL |
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| VIM-PTPRC-20-GRRE | 20 (40 μL) | 200 μL |
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| VIM-PTPRC-20-GROR | 20 (40 μL) | 200 μL |
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| VIM-PTPRC-20-GRGO | 20 (40 μL) | 200 μL |
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| VIM-PTPRC-20-GRGR | 20 (40 μL) | 200 μL |
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| VIM-PTPRC-20-GRAQ | 20 (40 μL) | 200 μL |
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| VIM-PTPRC-20-AQRE | 20 (40 μL) | 200 μL |
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| VIM-PTPRC-20-AQOR | 20 (40 μL) | 200 μL |
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| VIM-PTPRC-20-AQGO | 20 (40 μL) | 200 μL |
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| VIM-PTPRC-20-AQGR | 20 (40 μL) | 200 μL |
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| VIM-PTPRC-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPRC Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type C
Chromosome: CHR1: 198608136 -198726545
Locus: 1q31.3-q32.1
VIM Gene Summary
This gene encodes a type III intermediate filament protein. Intermediate filaments, along with microtubules and actin microfilaments, make up the cytoskeleton. The encoded protein is responsible for maintaining cell shape and integrity of the cytoplasm, and stabilizing cytoskeletal interactions. This protein is involved in neuritogenesis and cholesterol transport and functions as an organizer of a number of other critical proteins involved in cell attachment, migration, and signaling. Bacterial and viral pathogens have been shown to attach to this protein on the host cell surface. Mutations in this gene are associated with congenital cataracts in human patients. [provided by RefSeq, Aug 2017]
Gene Name: Vimentin
Chromosome: CHR10: 17270257 -17279592
Locus: 10p13
Gene Diseases
The VIM PTPRC Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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