VIM-CLCN3 Fusion FISH Probe
The VIM-CLCN3 Fusion FISH Probe is used to confirm a fusion of the VIM and CLCN3 genes. The fusion of the VIM and CLCN3 genes has been associated with Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| VIM-CLCN3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| VIM-CLCN3-20-RERE | 20 (40 μL) | 200 μL |
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| VIM-CLCN3-20-REOR | 20 (40 μL) | 200 μL |
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| VIM-CLCN3-20-REGO | 20 (40 μL) | 200 μL |
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| VIM-CLCN3-20-REGR | 20 (40 μL) | 200 μL |
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| VIM-CLCN3-20-REAQ | 20 (40 μL) | 200 μL |
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| VIM-CLCN3-20-ORRE | 20 (40 μL) | 200 μL |
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| VIM-CLCN3-20-OROR | 20 (40 μL) | 200 μL |
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| VIM-CLCN3-20-ORGO | 20 (40 μL) | 200 μL |
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| VIM-CLCN3-20-ORAQ | 20 (40 μL) | 200 μL |
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| VIM-CLCN3-20-GORE | 20 (40 μL) | 200 μL |
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| VIM-CLCN3-20-GOOR | 20 (40 μL) | 200 μL |
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| VIM-CLCN3-20-GOGO | 20 (40 μL) | 200 μL |
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| VIM-CLCN3-20-GOGR | 20 (40 μL) | 200 μL |
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| VIM-CLCN3-20-GOAQ | 20 (40 μL) | 200 μL |
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| VIM-CLCN3-20-GRRE | 20 (40 μL) | 200 μL |
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| VIM-CLCN3-20-GROR | 20 (40 μL) | 200 μL |
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| VIM-CLCN3-20-GRGO | 20 (40 μL) | 200 μL |
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| VIM-CLCN3-20-GRGR | 20 (40 μL) | 200 μL |
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| VIM-CLCN3-20-GRAQ | 20 (40 μL) | 200 μL |
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| VIM-CLCN3-20-AQRE | 20 (40 μL) | 200 μL |
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| VIM-CLCN3-20-AQOR | 20 (40 μL) | 200 μL |
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| VIM-CLCN3-20-AQGO | 20 (40 μL) | 200 μL |
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| VIM-CLCN3-20-AQGR | 20 (40 μL) | 200 μL |
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| VIM-CLCN3-20-AQAQ | 20 (40 μL) | 200 μL |
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CLCN3 Gene Summary
This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Chloride Voltage-gated Channel 3
Chromosome: CHR4: 170541671 -170644338
Locus: 4q33
VIM Gene Summary
This gene encodes a type III intermediate filament protein. Intermediate filaments, along with microtubules and actin microfilaments, make up the cytoskeleton. The encoded protein is responsible for maintaining cell shape and integrity of the cytoplasm, and stabilizing cytoskeletal interactions. This protein is involved in neuritogenesis and cholesterol transport and functions as an organizer of a number of other critical proteins involved in cell attachment, migration, and signaling. Bacterial and viral pathogens have been shown to attach to this protein on the host cell surface. Mutations in this gene are associated with congenital cataracts in human patients. [provided by RefSeq, Aug 2017]
Gene Name: Vimentin
Chromosome: CHR10: 17270257 -17279592
Locus: 10p13
Gene Diseases
The VIM CLCN3 Fusion has been associated with the following diseases:
| Disease Name |
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| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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