VHL-KIAA1430 Fusion FISH Probe
The VHL-KIAA1430 Fusion FISH Probe is used to confirm a fusion of the VHL and KIAA1430 genes. The fusion of the VHL and KIAA1430 genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| VHL-KIAA1430-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-RERE | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-REOR | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-REGO | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-REGR | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-REAQ | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-ORRE | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-OROR | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-ORGO | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-ORAQ | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-GORE | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-GOOR | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-GOGO | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-GOGR | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-GOAQ | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-GRRE | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-GROR | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-GRGO | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-GRGR | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-GRAQ | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-AQRE | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-AQOR | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-AQGO | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-AQGR | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-AQAQ | 20 (40 μL) | 200 μL |
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VHL Gene Summary
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Name: Von Hippel-Lindau Tumor Suppressor
Chromosome: CHR3: 10183318 -10195354
Locus: 3p25.3
Gene Diseases
The VHL KIAA1430 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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