VEGFA-HIST1H4H Fusion FISH Probe
The VEGFA-HIST1H4H Fusion FISH Probe is used to confirm a fusion of the VEGFA and HIST1H4H genes. The fusion of the VEGFA and HIST1H4H genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| VEGFA-HIST1H4H-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| VEGFA-HIST1H4H-20-RERE | 20 (40 μL) | 200 μL |
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| VEGFA-HIST1H4H-20-REOR | 20 (40 μL) | 200 μL |
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| VEGFA-HIST1H4H-20-REGO | 20 (40 μL) | 200 μL |
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| VEGFA-HIST1H4H-20-REGR | 20 (40 μL) | 200 μL |
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| VEGFA-HIST1H4H-20-REAQ | 20 (40 μL) | 200 μL |
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| VEGFA-HIST1H4H-20-ORRE | 20 (40 μL) | 200 μL |
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| VEGFA-HIST1H4H-20-OROR | 20 (40 μL) | 200 μL |
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| VEGFA-HIST1H4H-20-ORGO | 20 (40 μL) | 200 μL |
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| VEGFA-HIST1H4H-20-ORAQ | 20 (40 μL) | 200 μL |
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| VEGFA-HIST1H4H-20-GORE | 20 (40 μL) | 200 μL |
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| VEGFA-HIST1H4H-20-GOOR | 20 (40 μL) | 200 μL |
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| VEGFA-HIST1H4H-20-GOGO | 20 (40 μL) | 200 μL |
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| VEGFA-HIST1H4H-20-GOGR | 20 (40 μL) | 200 μL |
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| VEGFA-HIST1H4H-20-GOAQ | 20 (40 μL) | 200 μL |
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| VEGFA-HIST1H4H-20-GRRE | 20 (40 μL) | 200 μL |
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| VEGFA-HIST1H4H-20-GROR | 20 (40 μL) | 200 μL |
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| VEGFA-HIST1H4H-20-GRGO | 20 (40 μL) | 200 μL |
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| VEGFA-HIST1H4H-20-GRGR | 20 (40 μL) | 200 μL |
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| VEGFA-HIST1H4H-20-GRAQ | 20 (40 μL) | 200 μL |
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| VEGFA-HIST1H4H-20-AQRE | 20 (40 μL) | 200 μL |
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| VEGFA-HIST1H4H-20-AQOR | 20 (40 μL) | 200 μL |
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| VEGFA-HIST1H4H-20-AQGO | 20 (40 μL) | 200 μL |
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| VEGFA-HIST1H4H-20-AQGR | 20 (40 μL) | 200 μL |
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| VEGFA-HIST1H4H-20-AQAQ | 20 (40 μL) | 200 μL |
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VEGFA Gene Summary
This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015]
Gene Name: Vascular Endothelial Growth Factor A
Chromosome: CHR6: 43737945 -43754223
Locus: 6p21.1
HIST1H4H Gene Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
Gene Name: Histone Cluster 1 H4 Family Member H
Chromosome: CHR6: 26285353 -26285727
Locus: 6p22.2
Gene Diseases
The VEGFA HIST1H4H Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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