VCL-SEC24C Fusion FISH Probe
The VCL-SEC24C Fusion FISH Probe is used to confirm a fusion of the VCL and SEC24C genes. The fusion of the VCL and SEC24C genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| VCL-SEC24C-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| VCL-SEC24C-20-RERE | 20 (40 μL) | 200 μL |
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| VCL-SEC24C-20-REOR | 20 (40 μL) | 200 μL |
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| VCL-SEC24C-20-REGO | 20 (40 μL) | 200 μL |
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| VCL-SEC24C-20-REGR | 20 (40 μL) | 200 μL |
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| VCL-SEC24C-20-REAQ | 20 (40 μL) | 200 μL |
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| VCL-SEC24C-20-ORRE | 20 (40 μL) | 200 μL |
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| VCL-SEC24C-20-OROR | 20 (40 μL) | 200 μL |
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| VCL-SEC24C-20-ORGO | 20 (40 μL) | 200 μL |
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| VCL-SEC24C-20-ORAQ | 20 (40 μL) | 200 μL |
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| VCL-SEC24C-20-GORE | 20 (40 μL) | 200 μL |
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| VCL-SEC24C-20-GOOR | 20 (40 μL) | 200 μL |
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| VCL-SEC24C-20-GOGO | 20 (40 μL) | 200 μL |
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| VCL-SEC24C-20-GOGR | 20 (40 μL) | 200 μL |
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| VCL-SEC24C-20-GOAQ | 20 (40 μL) | 200 μL |
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| VCL-SEC24C-20-GRRE | 20 (40 μL) | 200 μL |
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| VCL-SEC24C-20-GROR | 20 (40 μL) | 200 μL |
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| VCL-SEC24C-20-GRGO | 20 (40 μL) | 200 μL |
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| VCL-SEC24C-20-GRGR | 20 (40 μL) | 200 μL |
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| VCL-SEC24C-20-GRAQ | 20 (40 μL) | 200 μL |
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| VCL-SEC24C-20-AQRE | 20 (40 μL) | 200 μL |
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| VCL-SEC24C-20-AQOR | 20 (40 μL) | 200 μL |
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| VCL-SEC24C-20-AQGO | 20 (40 μL) | 200 μL |
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| VCL-SEC24C-20-AQGR | 20 (40 μL) | 200 μL |
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| VCL-SEC24C-20-AQAQ | 20 (40 μL) | 200 μL |
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VCL Gene Summary
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Vinculin
Chromosome: CHR10: 75757871 -75879914
Locus: 10q22.2
SEC24C Gene Summary
The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The product of this gene may play a role in shaping the vesicle, as well as in cargo selection and concentration. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Gene Name: SEC24 Homolog C, COPII Coat Complex Component
Chromosome: CHR10: 75504130 -75531933
Locus: 10q22.2
Gene Diseases
The VCL SEC24C Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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