VBP1-BRCC3 Fusion FISH Probe
The VBP1-BRCC3 Fusion FISH Probe is used to confirm a fusion of the VBP1 and BRCC3 genes. The fusion of the VBP1 and BRCC3 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| VBP1-BRCC3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| VBP1-BRCC3-20-RERE | 20 (40 μL) | 200 μL |
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| VBP1-BRCC3-20-REOR | 20 (40 μL) | 200 μL |
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| VBP1-BRCC3-20-REGO | 20 (40 μL) | 200 μL |
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| VBP1-BRCC3-20-REGR | 20 (40 μL) | 200 μL |
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| VBP1-BRCC3-20-REAQ | 20 (40 μL) | 200 μL |
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| VBP1-BRCC3-20-ORRE | 20 (40 μL) | 200 μL |
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| VBP1-BRCC3-20-OROR | 20 (40 μL) | 200 μL |
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| VBP1-BRCC3-20-ORGO | 20 (40 μL) | 200 μL |
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| VBP1-BRCC3-20-ORAQ | 20 (40 μL) | 200 μL |
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| VBP1-BRCC3-20-GORE | 20 (40 μL) | 200 μL |
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| VBP1-BRCC3-20-GOOR | 20 (40 μL) | 200 μL |
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| VBP1-BRCC3-20-GOGO | 20 (40 μL) | 200 μL |
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| VBP1-BRCC3-20-GOGR | 20 (40 μL) | 200 μL |
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| VBP1-BRCC3-20-GOAQ | 20 (40 μL) | 200 μL |
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| VBP1-BRCC3-20-GRRE | 20 (40 μL) | 200 μL |
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| VBP1-BRCC3-20-GROR | 20 (40 μL) | 200 μL |
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| VBP1-BRCC3-20-GRGO | 20 (40 μL) | 200 μL |
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| VBP1-BRCC3-20-GRGR | 20 (40 μL) | 200 μL |
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| VBP1-BRCC3-20-GRAQ | 20 (40 μL) | 200 μL |
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| VBP1-BRCC3-20-AQRE | 20 (40 μL) | 200 μL |
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| VBP1-BRCC3-20-AQOR | 20 (40 μL) | 200 μL |
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| VBP1-BRCC3-20-AQGO | 20 (40 μL) | 200 μL |
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| VBP1-BRCC3-20-AQGR | 20 (40 μL) | 200 μL |
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| VBP1-BRCC3-20-AQAQ | 20 (40 μL) | 200 μL |
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VBP1 Gene Summary
The protein encoded by this gene interacts with the Von Hippel-Lindau protein to form an intracellular complex. The encoded protein functions as a chaperone protein, and may play a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm. Alternative splicing and the use of alternate transcription start sites results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Jan 2015]
Gene Name: VHL Binding Protein 1
Chromosome: CHRX: 154444700 -154468098
Locus: Xq28
BRCC3 Gene Summary
This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]
Gene Name: BRCA1/BRCA2-containing Complex Subunit 3
Chromosome: CHRX: 154299694 -154351349
Locus: Xq28
Gene Diseases
The VBP1 BRCC3 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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