VAV3-ZHX2 Fusion FISH Probe
The VAV3-ZHX2 Fusion FISH Probe is used to confirm a fusion of the VAV3 and ZHX2 genes. The fusion of the VAV3 and ZHX2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| VAV3-ZHX2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| VAV3-ZHX2-20-RERE | 20 (40 μL) | 200 μL |
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| VAV3-ZHX2-20-REOR | 20 (40 μL) | 200 μL |
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| VAV3-ZHX2-20-REGO | 20 (40 μL) | 200 μL |
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| VAV3-ZHX2-20-REGR | 20 (40 μL) | 200 μL |
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| VAV3-ZHX2-20-REAQ | 20 (40 μL) | 200 μL |
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| VAV3-ZHX2-20-ORRE | 20 (40 μL) | 200 μL |
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| VAV3-ZHX2-20-OROR | 20 (40 μL) | 200 μL |
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| VAV3-ZHX2-20-ORGO | 20 (40 μL) | 200 μL |
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| VAV3-ZHX2-20-ORAQ | 20 (40 μL) | 200 μL |
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| VAV3-ZHX2-20-GORE | 20 (40 μL) | 200 μL |
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| VAV3-ZHX2-20-GOOR | 20 (40 μL) | 200 μL |
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| VAV3-ZHX2-20-GOGO | 20 (40 μL) | 200 μL |
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| VAV3-ZHX2-20-GOGR | 20 (40 μL) | 200 μL |
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| VAV3-ZHX2-20-GOAQ | 20 (40 μL) | 200 μL |
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| VAV3-ZHX2-20-GRRE | 20 (40 μL) | 200 μL |
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| VAV3-ZHX2-20-GROR | 20 (40 μL) | 200 μL |
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| VAV3-ZHX2-20-GRGO | 20 (40 μL) | 200 μL |
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| VAV3-ZHX2-20-GRGR | 20 (40 μL) | 200 μL |
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| VAV3-ZHX2-20-GRAQ | 20 (40 μL) | 200 μL |
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| VAV3-ZHX2-20-AQRE | 20 (40 μL) | 200 μL |
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| VAV3-ZHX2-20-AQOR | 20 (40 μL) | 200 μL |
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| VAV3-ZHX2-20-AQGO | 20 (40 μL) | 200 μL |
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| VAV3-ZHX2-20-AQGR | 20 (40 μL) | 200 μL |
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| VAV3-ZHX2-20-AQAQ | 20 (40 μL) | 200 μL |
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VAV3 Gene Summary
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Vav Guanine Nucleotide Exchange Factor 3
Chromosome: CHR1: 108113781 -108507545
Locus: 1p13.3
ZHX2 Gene Summary
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008]
Gene Name: Zinc Fingers And Homeoboxes 2
Chromosome: CHR8: 123793900 -123986755
Locus: 8q24.13
Gene Diseases
The VAV3 ZHX2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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