VAV2-RXRA Fusion FISH Probe
The VAV2-RXRA Fusion FISH Probe is used to confirm a fusion of the VAV2 and RXRA genes. The fusion of the VAV2 and RXRA genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| VAV2-RXRA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| VAV2-RXRA-20-RERE | 20 (40 μL) | 200 μL |
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| VAV2-RXRA-20-REOR | 20 (40 μL) | 200 μL |
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| VAV2-RXRA-20-REGO | 20 (40 μL) | 200 μL |
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| VAV2-RXRA-20-REGR | 20 (40 μL) | 200 μL |
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| VAV2-RXRA-20-REAQ | 20 (40 μL) | 200 μL |
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| VAV2-RXRA-20-ORRE | 20 (40 μL) | 200 μL |
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| VAV2-RXRA-20-OROR | 20 (40 μL) | 200 μL |
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| VAV2-RXRA-20-ORGO | 20 (40 μL) | 200 μL |
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| VAV2-RXRA-20-ORAQ | 20 (40 μL) | 200 μL |
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| VAV2-RXRA-20-GORE | 20 (40 μL) | 200 μL |
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| VAV2-RXRA-20-GOOR | 20 (40 μL) | 200 μL |
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| VAV2-RXRA-20-GOGO | 20 (40 μL) | 200 μL |
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| VAV2-RXRA-20-GOGR | 20 (40 μL) | 200 μL |
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| VAV2-RXRA-20-GOAQ | 20 (40 μL) | 200 μL |
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| VAV2-RXRA-20-GRRE | 20 (40 μL) | 200 μL |
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| VAV2-RXRA-20-GROR | 20 (40 μL) | 200 μL |
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| VAV2-RXRA-20-GRGO | 20 (40 μL) | 200 μL |
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| VAV2-RXRA-20-GRGR | 20 (40 μL) | 200 μL |
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| VAV2-RXRA-20-GRAQ | 20 (40 μL) | 200 μL |
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| VAV2-RXRA-20-AQRE | 20 (40 μL) | 200 μL |
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| VAV2-RXRA-20-AQOR | 20 (40 μL) | 200 μL |
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| VAV2-RXRA-20-AQGO | 20 (40 μL) | 200 μL |
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| VAV2-RXRA-20-AQGR | 20 (40 μL) | 200 μL |
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| VAV2-RXRA-20-AQAQ | 20 (40 μL) | 200 μL |
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RXRA Gene Summary
Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Name: Retinoid X Receptor Alpha
Chromosome: CHR9: 137218315 -137332431
Locus: 9q34.2
VAV2 Gene Summary
VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Name: Vav Guanine Nucleotide Exchange Factor 2
Chromosome: CHR9: 136627015 -136857446
Locus: 9q34.2
Gene Diseases
The VAV2 RXRA Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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