VAMP1-CHD4 Fusion FISH Probe
The VAMP1-CHD4 Fusion FISH Probe is used to confirm a fusion of the VAMP1 and CHD4 genes. The fusion of the VAMP1 and CHD4 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| VAMP1-CHD4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| VAMP1-CHD4-20-RERE | 20 (40 μL) | 200 μL |
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| VAMP1-CHD4-20-REOR | 20 (40 μL) | 200 μL |
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| VAMP1-CHD4-20-REGO | 20 (40 μL) | 200 μL |
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| VAMP1-CHD4-20-REGR | 20 (40 μL) | 200 μL |
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| VAMP1-CHD4-20-REAQ | 20 (40 μL) | 200 μL |
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| VAMP1-CHD4-20-ORRE | 20 (40 μL) | 200 μL |
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| VAMP1-CHD4-20-OROR | 20 (40 μL) | 200 μL |
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| VAMP1-CHD4-20-ORGO | 20 (40 μL) | 200 μL |
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| VAMP1-CHD4-20-ORAQ | 20 (40 μL) | 200 μL |
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| VAMP1-CHD4-20-GORE | 20 (40 μL) | 200 μL |
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| VAMP1-CHD4-20-GOOR | 20 (40 μL) | 200 μL |
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| VAMP1-CHD4-20-GOGO | 20 (40 μL) | 200 μL |
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| VAMP1-CHD4-20-GOGR | 20 (40 μL) | 200 μL |
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| VAMP1-CHD4-20-GOAQ | 20 (40 μL) | 200 μL |
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| VAMP1-CHD4-20-GRRE | 20 (40 μL) | 200 μL |
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| VAMP1-CHD4-20-GROR | 20 (40 μL) | 200 μL |
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| VAMP1-CHD4-20-GRGO | 20 (40 μL) | 200 μL |
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| VAMP1-CHD4-20-GRGR | 20 (40 μL) | 200 μL |
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| VAMP1-CHD4-20-GRAQ | 20 (40 μL) | 200 μL |
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| VAMP1-CHD4-20-AQRE | 20 (40 μL) | 200 μL |
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| VAMP1-CHD4-20-AQOR | 20 (40 μL) | 200 μL |
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| VAMP1-CHD4-20-AQGO | 20 (40 μL) | 200 μL |
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| VAMP1-CHD4-20-AQGR | 20 (40 μL) | 200 μL |
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| VAMP1-CHD4-20-AQAQ | 20 (40 μL) | 200 μL |
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CHD4 Gene Summary
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Gene Name: Chromodomain Helicase DNA Binding Protein 4
Chromosome: CHR12: 6679247 -6716551
Locus: 12p13.31
VAMP1 Gene Summary
Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014]
Gene Name: Vesicle Associated Membrane Protein 1
Chromosome: CHR12: 6571403 -6579843
Locus: 12p13.31
Gene Diseases
The VAMP1 CHD4 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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