VAC14-CDH8 Fusion FISH Probe
The VAC14-CDH8 Fusion FISH Probe is used to confirm a fusion of the VAC14 and CDH8 genes. The fusion of the VAC14 and CDH8 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| VAC14-CDH8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| VAC14-CDH8-20-RERE | 20 (40 μL) | 200 μL |
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| VAC14-CDH8-20-REOR | 20 (40 μL) | 200 μL |
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| VAC14-CDH8-20-REGO | 20 (40 μL) | 200 μL |
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| VAC14-CDH8-20-REGR | 20 (40 μL) | 200 μL |
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| VAC14-CDH8-20-REAQ | 20 (40 μL) | 200 μL |
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| VAC14-CDH8-20-ORRE | 20 (40 μL) | 200 μL |
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| VAC14-CDH8-20-OROR | 20 (40 μL) | 200 μL |
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| VAC14-CDH8-20-ORGO | 20 (40 μL) | 200 μL |
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| VAC14-CDH8-20-ORAQ | 20 (40 μL) | 200 μL |
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| VAC14-CDH8-20-GORE | 20 (40 μL) | 200 μL |
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| VAC14-CDH8-20-GOOR | 20 (40 μL) | 200 μL |
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| VAC14-CDH8-20-GOGO | 20 (40 μL) | 200 μL |
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| VAC14-CDH8-20-GOGR | 20 (40 μL) | 200 μL |
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| VAC14-CDH8-20-GOAQ | 20 (40 μL) | 200 μL |
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| VAC14-CDH8-20-GRRE | 20 (40 μL) | 200 μL |
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| VAC14-CDH8-20-GROR | 20 (40 μL) | 200 μL |
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| VAC14-CDH8-20-GRGO | 20 (40 μL) | 200 μL |
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| VAC14-CDH8-20-GRGR | 20 (40 μL) | 200 μL |
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| VAC14-CDH8-20-GRAQ | 20 (40 μL) | 200 μL |
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| VAC14-CDH8-20-AQRE | 20 (40 μL) | 200 μL |
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| VAC14-CDH8-20-AQOR | 20 (40 μL) | 200 μL |
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| VAC14-CDH8-20-AQGO | 20 (40 μL) | 200 μL |
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| VAC14-CDH8-20-AQGR | 20 (40 μL) | 200 μL |
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| VAC14-CDH8-20-AQAQ | 20 (40 μL) | 200 μL |
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CDH8 Gene Summary
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided by RefSeq, Jul 2008]
Gene Name: Cadherin 8
Chromosome: CHR16: 61685914 -62070739
Locus: 16q21
VAC14 Gene Summary
This gene encodes a scaffold protein that is a component of the PIKfyve protein kinase complex. This complex is responsible for the synthesis of phosphatidylinositol 3,5-bisphosphate, an important component of cellular membranes, from phosphatidylinositol 3-phosphate. Mice lacking a functional copy of this gene exhibit severe neurodegeneration. Mutations in the human gene have been identified in patients with a childhood onset progressive neurological disorder characterized by impaired movement, dystonia, and striatal abnormalities. [provided by RefSeq, May 2017]
Gene Name: Vac14, PIKFYVE Complex Component
Chromosome: CHR16: 70721341 -70835061
Locus: 16q22.1-q22.2
Gene Diseases
The VAC14 CDH8 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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