UVRAG-PCBD1 Fusion FISH Probe
The UVRAG-PCBD1 Fusion FISH Probe is used to confirm a fusion of the UVRAG and PCBD1 genes. The fusion of the UVRAG and PCBD1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UVRAG-PCBD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UVRAG-PCBD1-20-RERE | 20 (40 μL) | 200 μL |
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| UVRAG-PCBD1-20-REOR | 20 (40 μL) | 200 μL |
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| UVRAG-PCBD1-20-REGO | 20 (40 μL) | 200 μL |
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| UVRAG-PCBD1-20-REGR | 20 (40 μL) | 200 μL |
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| UVRAG-PCBD1-20-REAQ | 20 (40 μL) | 200 μL |
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| UVRAG-PCBD1-20-ORRE | 20 (40 μL) | 200 μL |
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| UVRAG-PCBD1-20-OROR | 20 (40 μL) | 200 μL |
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| UVRAG-PCBD1-20-ORGO | 20 (40 μL) | 200 μL |
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| UVRAG-PCBD1-20-ORAQ | 20 (40 μL) | 200 μL |
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| UVRAG-PCBD1-20-GORE | 20 (40 μL) | 200 μL |
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| UVRAG-PCBD1-20-GOOR | 20 (40 μL) | 200 μL |
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| UVRAG-PCBD1-20-GOGO | 20 (40 μL) | 200 μL |
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| UVRAG-PCBD1-20-GOGR | 20 (40 μL) | 200 μL |
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| UVRAG-PCBD1-20-GOAQ | 20 (40 μL) | 200 μL |
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| UVRAG-PCBD1-20-GRRE | 20 (40 μL) | 200 μL |
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| UVRAG-PCBD1-20-GROR | 20 (40 μL) | 200 μL |
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| UVRAG-PCBD1-20-GRGO | 20 (40 μL) | 200 μL |
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| UVRAG-PCBD1-20-GRGR | 20 (40 μL) | 200 μL |
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| UVRAG-PCBD1-20-GRAQ | 20 (40 μL) | 200 μL |
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| UVRAG-PCBD1-20-AQRE | 20 (40 μL) | 200 μL |
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| UVRAG-PCBD1-20-AQOR | 20 (40 μL) | 200 μL |
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| UVRAG-PCBD1-20-AQGO | 20 (40 μL) | 200 μL |
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| UVRAG-PCBD1-20-AQGR | 20 (40 μL) | 200 μL |
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| UVRAG-PCBD1-20-AQAQ | 20 (40 μL) | 200 μL |
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PCBD1 Gene Summary
This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. A deficiency of this enzyme leads to hyperphenylalaninemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Name: Pterin-4 Alpha-carbinolamine Dehydratase 1
Chromosome: CHR10: 72643266 -72648541
Locus: 10q22.1
UVRAG Gene Summary
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]
Gene Name: UV Radiation Resistance Associated
Chromosome: CHR11: 75526211 -75855282
Locus: 11q13.5
Gene Diseases
The UVRAG PCBD1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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