UVRAG-PACRG Fusion FISH Probe
The UVRAG-PACRG Fusion FISH Probe is used to confirm a fusion of the UVRAG and PACRG genes. The fusion of the UVRAG and PACRG genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UVRAG-PACRG-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UVRAG-PACRG-20-RERE | 20 (40 μL) | 200 μL |
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| UVRAG-PACRG-20-REOR | 20 (40 μL) | 200 μL |
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| UVRAG-PACRG-20-REGO | 20 (40 μL) | 200 μL |
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| UVRAG-PACRG-20-REGR | 20 (40 μL) | 200 μL |
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| UVRAG-PACRG-20-REAQ | 20 (40 μL) | 200 μL |
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| UVRAG-PACRG-20-ORRE | 20 (40 μL) | 200 μL |
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| UVRAG-PACRG-20-OROR | 20 (40 μL) | 200 μL |
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| UVRAG-PACRG-20-ORGO | 20 (40 μL) | 200 μL |
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| UVRAG-PACRG-20-ORAQ | 20 (40 μL) | 200 μL |
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| UVRAG-PACRG-20-GORE | 20 (40 μL) | 200 μL |
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| UVRAG-PACRG-20-GOOR | 20 (40 μL) | 200 μL |
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| UVRAG-PACRG-20-GOGO | 20 (40 μL) | 200 μL |
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| UVRAG-PACRG-20-GOGR | 20 (40 μL) | 200 μL |
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| UVRAG-PACRG-20-GOAQ | 20 (40 μL) | 200 μL |
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| UVRAG-PACRG-20-GRRE | 20 (40 μL) | 200 μL |
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| UVRAG-PACRG-20-GROR | 20 (40 μL) | 200 μL |
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| UVRAG-PACRG-20-GRGO | 20 (40 μL) | 200 μL |
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| UVRAG-PACRG-20-GRGR | 20 (40 μL) | 200 μL |
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| UVRAG-PACRG-20-GRAQ | 20 (40 μL) | 200 μL |
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| UVRAG-PACRG-20-AQRE | 20 (40 μL) | 200 μL |
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| UVRAG-PACRG-20-AQOR | 20 (40 μL) | 200 μL |
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| UVRAG-PACRG-20-AQGO | 20 (40 μL) | 200 μL |
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| UVRAG-PACRG-20-AQGR | 20 (40 μL) | 200 μL |
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| UVRAG-PACRG-20-AQAQ | 20 (40 μL) | 200 μL |
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UVRAG Gene Summary
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]
Gene Name: UV Radiation Resistance Associated
Chromosome: CHR11: 75526211 -75855282
Locus: 11q13.5
PACRG Gene Summary
This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Parkin Coregulated
Chromosome: CHR6: 163148163 -163736524
Locus: 6q26
Gene Diseases
The UVRAG PACRG Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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