UVRAG-OTUB1 Fusion FISH Probe
The UVRAG-OTUB1 Fusion FISH Probe is used to confirm a fusion of the UVRAG and OTUB1 genes. The fusion of the UVRAG and OTUB1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UVRAG-OTUB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UVRAG-OTUB1-20-RERE | 20 (40 μL) | 200 μL |
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| UVRAG-OTUB1-20-REOR | 20 (40 μL) | 200 μL |
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| UVRAG-OTUB1-20-REGO | 20 (40 μL) | 200 μL |
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| UVRAG-OTUB1-20-REGR | 20 (40 μL) | 200 μL |
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| UVRAG-OTUB1-20-REAQ | 20 (40 μL) | 200 μL |
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| UVRAG-OTUB1-20-ORRE | 20 (40 μL) | 200 μL |
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| UVRAG-OTUB1-20-OROR | 20 (40 μL) | 200 μL |
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| UVRAG-OTUB1-20-ORGO | 20 (40 μL) | 200 μL |
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| UVRAG-OTUB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| UVRAG-OTUB1-20-GORE | 20 (40 μL) | 200 μL |
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| UVRAG-OTUB1-20-GOOR | 20 (40 μL) | 200 μL |
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| UVRAG-OTUB1-20-GOGO | 20 (40 μL) | 200 μL |
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| UVRAG-OTUB1-20-GOGR | 20 (40 μL) | 200 μL |
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| UVRAG-OTUB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| UVRAG-OTUB1-20-GRRE | 20 (40 μL) | 200 μL |
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| UVRAG-OTUB1-20-GROR | 20 (40 μL) | 200 μL |
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| UVRAG-OTUB1-20-GRGO | 20 (40 μL) | 200 μL |
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| UVRAG-OTUB1-20-GRGR | 20 (40 μL) | 200 μL |
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| UVRAG-OTUB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| UVRAG-OTUB1-20-AQRE | 20 (40 μL) | 200 μL |
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| UVRAG-OTUB1-20-AQOR | 20 (40 μL) | 200 μL |
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| UVRAG-OTUB1-20-AQGO | 20 (40 μL) | 200 μL |
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| UVRAG-OTUB1-20-AQGR | 20 (40 μL) | 200 μL |
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| UVRAG-OTUB1-20-AQAQ | 20 (40 μL) | 200 μL |
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UVRAG Gene Summary
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]
Gene Name: UV Radiation Resistance Associated
Chromosome: CHR11: 75526211 -75855282
Locus: 11q13.5
OTUB1 Gene Summary
The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Gene Name: OTU Deubiquitinase, Ubiquitin Aldehyde Binding 1
Chromosome: CHR11: 63753324 -63765892
Locus: 11q13.1
Gene Diseases
The UVRAG OTUB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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