UVRAG-KCNE3 Fusion FISH Probe
The UVRAG-KCNE3 Fusion FISH Probe is used to confirm a fusion of the UVRAG and KCNE3 genes. The fusion of the UVRAG and KCNE3 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UVRAG-KCNE3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UVRAG-KCNE3-20-RERE | 20 (40 μL) | 200 μL |
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| UVRAG-KCNE3-20-REOR | 20 (40 μL) | 200 μL |
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| UVRAG-KCNE3-20-REGO | 20 (40 μL) | 200 μL |
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| UVRAG-KCNE3-20-REGR | 20 (40 μL) | 200 μL |
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| UVRAG-KCNE3-20-REAQ | 20 (40 μL) | 200 μL |
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| UVRAG-KCNE3-20-ORRE | 20 (40 μL) | 200 μL |
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| UVRAG-KCNE3-20-OROR | 20 (40 μL) | 200 μL |
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| UVRAG-KCNE3-20-ORGO | 20 (40 μL) | 200 μL |
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| UVRAG-KCNE3-20-ORAQ | 20 (40 μL) | 200 μL |
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| UVRAG-KCNE3-20-GORE | 20 (40 μL) | 200 μL |
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| UVRAG-KCNE3-20-GOOR | 20 (40 μL) | 200 μL |
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| UVRAG-KCNE3-20-GOGO | 20 (40 μL) | 200 μL |
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| UVRAG-KCNE3-20-GOGR | 20 (40 μL) | 200 μL |
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| UVRAG-KCNE3-20-GOAQ | 20 (40 μL) | 200 μL |
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| UVRAG-KCNE3-20-GRRE | 20 (40 μL) | 200 μL |
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| UVRAG-KCNE3-20-GROR | 20 (40 μL) | 200 μL |
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| UVRAG-KCNE3-20-GRGO | 20 (40 μL) | 200 μL |
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| UVRAG-KCNE3-20-GRGR | 20 (40 μL) | 200 μL |
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| UVRAG-KCNE3-20-GRAQ | 20 (40 μL) | 200 μL |
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| UVRAG-KCNE3-20-AQRE | 20 (40 μL) | 200 μL |
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| UVRAG-KCNE3-20-AQOR | 20 (40 μL) | 200 μL |
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| UVRAG-KCNE3-20-AQGO | 20 (40 μL) | 200 μL |
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| UVRAG-KCNE3-20-AQGR | 20 (40 μL) | 200 μL |
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| UVRAG-KCNE3-20-AQAQ | 20 (40 μL) | 200 μL |
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UVRAG Gene Summary
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]
Gene Name: UV Radiation Resistance Associated
Chromosome: CHR11: 75526211 -75855282
Locus: 11q13.5
KCNE3 Gene Summary
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. A missense mutation in this gene is associated with hypokalemic periodic paralysis. [provided by RefSeq, Jul 2008]
Gene Name: Potassium Voltage-gated Channel Subfamily E Regulatory Subunit 3
Chromosome: CHR11: 74165885 -74178600
Locus: 11q13.4
Gene Diseases
The UVRAG KCNE3 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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