UTRN-PLAGL1 Fusion FISH Probe
The UTRN-PLAGL1 Fusion FISH Probe is used to confirm a fusion of the UTRN and PLAGL1 genes. The fusion of the UTRN and PLAGL1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UTRN-PLAGL1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UTRN-PLAGL1-20-RERE | 20 (40 μL) | 200 μL |
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| UTRN-PLAGL1-20-REOR | 20 (40 μL) | 200 μL |
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| UTRN-PLAGL1-20-REGO | 20 (40 μL) | 200 μL |
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| UTRN-PLAGL1-20-REGR | 20 (40 μL) | 200 μL |
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| UTRN-PLAGL1-20-REAQ | 20 (40 μL) | 200 μL |
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| UTRN-PLAGL1-20-ORRE | 20 (40 μL) | 200 μL |
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| UTRN-PLAGL1-20-OROR | 20 (40 μL) | 200 μL |
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| UTRN-PLAGL1-20-ORGO | 20 (40 μL) | 200 μL |
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| UTRN-PLAGL1-20-ORAQ | 20 (40 μL) | 200 μL |
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| UTRN-PLAGL1-20-GORE | 20 (40 μL) | 200 μL |
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| UTRN-PLAGL1-20-GOOR | 20 (40 μL) | 200 μL |
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| UTRN-PLAGL1-20-GOGO | 20 (40 μL) | 200 μL |
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| UTRN-PLAGL1-20-GOGR | 20 (40 μL) | 200 μL |
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| UTRN-PLAGL1-20-GOAQ | 20 (40 μL) | 200 μL |
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| UTRN-PLAGL1-20-GRRE | 20 (40 μL) | 200 μL |
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| UTRN-PLAGL1-20-GROR | 20 (40 μL) | 200 μL |
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| UTRN-PLAGL1-20-GRGO | 20 (40 μL) | 200 μL |
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| UTRN-PLAGL1-20-GRGR | 20 (40 μL) | 200 μL |
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| UTRN-PLAGL1-20-GRAQ | 20 (40 μL) | 200 μL |
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| UTRN-PLAGL1-20-AQRE | 20 (40 μL) | 200 μL |
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| UTRN-PLAGL1-20-AQOR | 20 (40 μL) | 200 μL |
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| UTRN-PLAGL1-20-AQGO | 20 (40 μL) | 200 μL |
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| UTRN-PLAGL1-20-AQGR | 20 (40 μL) | 200 μL |
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| UTRN-PLAGL1-20-AQAQ | 20 (40 μL) | 200 μL |
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PLAGL1 Gene Summary
This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015]
Gene Name: PLAG1 Like Zinc Finger 1
Chromosome: CHR6: 144261436 -144385735
Locus: 6q24.2
UTRN Gene Summary
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Gene Name: Utrophin
Chromosome: CHR6: 144612872 -145174170
Locus: 6q24.2
Gene Diseases
The UTRN PLAGL1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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