UTRN-MMADHC Fusion FISH Probe
The UTRN-MMADHC Fusion FISH Probe is used to confirm a fusion of the UTRN and MMADHC genes. The fusion of the UTRN and MMADHC genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UTRN-MMADHC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UTRN-MMADHC-20-RERE | 20 (40 μL) | 200 μL |
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| UTRN-MMADHC-20-REOR | 20 (40 μL) | 200 μL |
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| UTRN-MMADHC-20-REGO | 20 (40 μL) | 200 μL |
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| UTRN-MMADHC-20-REGR | 20 (40 μL) | 200 μL |
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| UTRN-MMADHC-20-REAQ | 20 (40 μL) | 200 μL |
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| UTRN-MMADHC-20-ORRE | 20 (40 μL) | 200 μL |
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| UTRN-MMADHC-20-OROR | 20 (40 μL) | 200 μL |
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| UTRN-MMADHC-20-ORGO | 20 (40 μL) | 200 μL |
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| UTRN-MMADHC-20-ORAQ | 20 (40 μL) | 200 μL |
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| UTRN-MMADHC-20-GORE | 20 (40 μL) | 200 μL |
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| UTRN-MMADHC-20-GOOR | 20 (40 μL) | 200 μL |
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| UTRN-MMADHC-20-GOGO | 20 (40 μL) | 200 μL |
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| UTRN-MMADHC-20-GOGR | 20 (40 μL) | 200 μL |
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| UTRN-MMADHC-20-GOAQ | 20 (40 μL) | 200 μL |
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| UTRN-MMADHC-20-GRRE | 20 (40 μL) | 200 μL |
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| UTRN-MMADHC-20-GROR | 20 (40 μL) | 200 μL |
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| UTRN-MMADHC-20-GRGO | 20 (40 μL) | 200 μL |
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| UTRN-MMADHC-20-GRGR | 20 (40 μL) | 200 μL |
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| UTRN-MMADHC-20-GRAQ | 20 (40 μL) | 200 μL |
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| UTRN-MMADHC-20-AQRE | 20 (40 μL) | 200 μL |
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| UTRN-MMADHC-20-AQOR | 20 (40 μL) | 200 μL |
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| UTRN-MMADHC-20-AQGO | 20 (40 μL) | 200 μL |
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| UTRN-MMADHC-20-AQGR | 20 (40 μL) | 200 μL |
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| UTRN-MMADHC-20-AQAQ | 20 (40 μL) | 200 μL |
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UTRN Gene Summary
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Gene Name: Utrophin
Chromosome: CHR6: 144612872 -145174170
Locus: 6q24.2
MMADHC Gene Summary
This gene encodes a mitochondrial protein that is involved in an early step of vitamin B12 metabolism. Vitamin B12 (cobalamin) is essential for normal development and survival in humans. Mutations in this gene cause methylmalonic aciduria and homocystinuria type cblD (MMADHC), a disorder of cobalamin metabolism that is characterized by decreased levels of the coenzymes adenosylcobalamin and methylcobalamin. Pseudogenes have been identified on chromosomes 11 and X.[provided by RefSeq, Nov 2008]
Gene Name: Methylmalonic Aciduria And Homocystinuria, CblD Type
Chromosome: CHR2: 150426146 -150444330
Locus: 2q23.2
Gene Diseases
The UTRN MMADHC Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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