UTRN-EIF4G3 Fusion FISH Probe
The UTRN-EIF4G3 Fusion FISH Probe is used to confirm a fusion of the UTRN and EIF4G3 genes. The fusion of the UTRN and EIF4G3 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| UTRN-EIF4G3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| UTRN-EIF4G3-20-RERE | 20 (40 μL) | 200 μL |
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| UTRN-EIF4G3-20-REOR | 20 (40 μL) | 200 μL |
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| UTRN-EIF4G3-20-REGO | 20 (40 μL) | 200 μL |
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| UTRN-EIF4G3-20-REGR | 20 (40 μL) | 200 μL |
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| UTRN-EIF4G3-20-REAQ | 20 (40 μL) | 200 μL |
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| UTRN-EIF4G3-20-ORRE | 20 (40 μL) | 200 μL |
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| UTRN-EIF4G3-20-OROR | 20 (40 μL) | 200 μL |
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| UTRN-EIF4G3-20-ORGO | 20 (40 μL) | 200 μL |
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| UTRN-EIF4G3-20-ORAQ | 20 (40 μL) | 200 μL |
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| UTRN-EIF4G3-20-GORE | 20 (40 μL) | 200 μL |
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| UTRN-EIF4G3-20-GOOR | 20 (40 μL) | 200 μL |
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| UTRN-EIF4G3-20-GOGO | 20 (40 μL) | 200 μL |
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| UTRN-EIF4G3-20-GOGR | 20 (40 μL) | 200 μL |
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| UTRN-EIF4G3-20-GOAQ | 20 (40 μL) | 200 μL |
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| UTRN-EIF4G3-20-GRRE | 20 (40 μL) | 200 μL |
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| UTRN-EIF4G3-20-GROR | 20 (40 μL) | 200 μL |
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| UTRN-EIF4G3-20-GRGO | 20 (40 μL) | 200 μL |
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| UTRN-EIF4G3-20-GRGR | 20 (40 μL) | 200 μL |
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| UTRN-EIF4G3-20-GRAQ | 20 (40 μL) | 200 μL |
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| UTRN-EIF4G3-20-AQRE | 20 (40 μL) | 200 μL |
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| UTRN-EIF4G3-20-AQOR | 20 (40 μL) | 200 μL |
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| UTRN-EIF4G3-20-AQGO | 20 (40 μL) | 200 μL |
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| UTRN-EIF4G3-20-AQGR | 20 (40 μL) | 200 μL |
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| UTRN-EIF4G3-20-AQAQ | 20 (40 μL) | 200 μL |
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UTRN Gene Summary
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Gene Name: Utrophin
Chromosome: CHR6: 144612872 -145174170
Locus: 6q24.2
EIF4G3 Gene Summary
The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]
Gene Name: Eukaryotic Translation Initiation Factor 4 Gamma 3
Chromosome: CHR1: 21132784 -21503381
Locus: 1p36.12
Gene Diseases
The UTRN EIF4G3 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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