USP8-TSPAN3 Fusion FISH Probe
The USP8-TSPAN3 Fusion FISH Probe is used to confirm a fusion of the USP8 and TSPAN3 genes. The fusion of the USP8 and TSPAN3 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| USP8-TSPAN3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| USP8-TSPAN3-20-RERE | 20 (40 μL) | 200 μL |
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| USP8-TSPAN3-20-REOR | 20 (40 μL) | 200 μL |
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| USP8-TSPAN3-20-REGO | 20 (40 μL) | 200 μL |
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| USP8-TSPAN3-20-REGR | 20 (40 μL) | 200 μL |
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| USP8-TSPAN3-20-REAQ | 20 (40 μL) | 200 μL |
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| USP8-TSPAN3-20-ORRE | 20 (40 μL) | 200 μL |
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| USP8-TSPAN3-20-OROR | 20 (40 μL) | 200 μL |
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| USP8-TSPAN3-20-ORGO | 20 (40 μL) | 200 μL |
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| USP8-TSPAN3-20-ORAQ | 20 (40 μL) | 200 μL |
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| USP8-TSPAN3-20-GORE | 20 (40 μL) | 200 μL |
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| USP8-TSPAN3-20-GOOR | 20 (40 μL) | 200 μL |
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| USP8-TSPAN3-20-GOGO | 20 (40 μL) | 200 μL |
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| USP8-TSPAN3-20-GOGR | 20 (40 μL) | 200 μL |
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| USP8-TSPAN3-20-GOAQ | 20 (40 μL) | 200 μL |
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| USP8-TSPAN3-20-GRRE | 20 (40 μL) | 200 μL |
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| USP8-TSPAN3-20-GROR | 20 (40 μL) | 200 μL |
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| USP8-TSPAN3-20-GRGO | 20 (40 μL) | 200 μL |
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| USP8-TSPAN3-20-GRGR | 20 (40 μL) | 200 μL |
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| USP8-TSPAN3-20-GRAQ | 20 (40 μL) | 200 μL |
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| USP8-TSPAN3-20-AQRE | 20 (40 μL) | 200 μL |
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| USP8-TSPAN3-20-AQOR | 20 (40 μL) | 200 μL |
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| USP8-TSPAN3-20-AQGO | 20 (40 μL) | 200 μL |
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| USP8-TSPAN3-20-AQGR | 20 (40 μL) | 200 μL |
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| USP8-TSPAN3-20-AQAQ | 20 (40 μL) | 200 μL |
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USP8 Gene Summary
This gene encodes a protein that belongs to the ubiquitin-specific processing protease family of proteins. The encoded protein is thought to regulate the morphology of the endosome by ubiquitination of proteins on this organelle and is involved in cargo sorting and membrane trafficking at the early endosome stage. This protein is required for the cell to enter the S phase of the cell cycle and also functions as a positive regulator in the Hedgehog signaling pathway in development. Pseudogenes of this gene are present on chromosomes 2 and 6. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Name: Ubiquitin Specific Peptidase 8
Chromosome: CHR15: 50716578 -50793277
Locus: 15q21.2
TSPAN3 Gene Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. Multiple alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Dec 2009]
Gene Name: Tetraspanin 3
Chromosome: CHR15: 77336359 -77363570
Locus: 15q24.3
Gene Diseases
The USP8 TSPAN3 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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