USP8-BDP1 Fusion FISH Probe
The USP8-BDP1 Fusion FISH Probe is used to confirm a fusion of the USP8 and BDP1 genes. The fusion of the USP8 and BDP1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| USP8-BDP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| USP8-BDP1-20-RERE | 20 (40 μL) | 200 μL |
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| USP8-BDP1-20-REOR | 20 (40 μL) | 200 μL |
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| USP8-BDP1-20-REGO | 20 (40 μL) | 200 μL |
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| USP8-BDP1-20-REGR | 20 (40 μL) | 200 μL |
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| USP8-BDP1-20-REAQ | 20 (40 μL) | 200 μL |
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| USP8-BDP1-20-ORRE | 20 (40 μL) | 200 μL |
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| USP8-BDP1-20-OROR | 20 (40 μL) | 200 μL |
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| USP8-BDP1-20-ORGO | 20 (40 μL) | 200 μL |
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| USP8-BDP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| USP8-BDP1-20-GORE | 20 (40 μL) | 200 μL |
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| USP8-BDP1-20-GOOR | 20 (40 μL) | 200 μL |
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| USP8-BDP1-20-GOGO | 20 (40 μL) | 200 μL |
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| USP8-BDP1-20-GOGR | 20 (40 μL) | 200 μL |
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| USP8-BDP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| USP8-BDP1-20-GRRE | 20 (40 μL) | 200 μL |
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| USP8-BDP1-20-GROR | 20 (40 μL) | 200 μL |
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| USP8-BDP1-20-GRGO | 20 (40 μL) | 200 μL |
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| USP8-BDP1-20-GRGR | 20 (40 μL) | 200 μL |
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| USP8-BDP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| USP8-BDP1-20-AQRE | 20 (40 μL) | 200 μL |
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| USP8-BDP1-20-AQOR | 20 (40 μL) | 200 μL |
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| USP8-BDP1-20-AQGO | 20 (40 μL) | 200 μL |
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| USP8-BDP1-20-AQGR | 20 (40 μL) | 200 μL |
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| USP8-BDP1-20-AQAQ | 20 (40 μL) | 200 μL |
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USP8 Gene Summary
This gene encodes a protein that belongs to the ubiquitin-specific processing protease family of proteins. The encoded protein is thought to regulate the morphology of the endosome by ubiquitination of proteins on this organelle and is involved in cargo sorting and membrane trafficking at the early endosome stage. This protein is required for the cell to enter the S phase of the cell cycle and also functions as a positive regulator in the Hedgehog signaling pathway in development. Pseudogenes of this gene are present on chromosomes 2 and 6. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Name: Ubiquitin Specific Peptidase 8
Chromosome: CHR15: 50716578 -50793277
Locus: 15q21.2
BDP1 Gene Summary
The product of this gene is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase II during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription. [provided by RefSeq, Jul 2008]
Gene Name: B Double Prime 1, Subunit Of RNA Polymerase III Transcription Initiation Factor IIIB
Chromosome: CHR5: 70751441 -70863649
Locus: 5q13.2
Gene Diseases
The USP8 BDP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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