USP7-SMARCA2 Fusion FISH Probe
The USP7-SMARCA2 Fusion FISH Probe is used to confirm a fusion of the USP7 and SMARCA2 genes. The fusion of the USP7 and SMARCA2 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| USP7-SMARCA2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| USP7-SMARCA2-20-RERE | 20 (40 μL) | 200 μL |
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| USP7-SMARCA2-20-REOR | 20 (40 μL) | 200 μL |
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| USP7-SMARCA2-20-REGO | 20 (40 μL) | 200 μL |
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| USP7-SMARCA2-20-REGR | 20 (40 μL) | 200 μL |
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| USP7-SMARCA2-20-REAQ | 20 (40 μL) | 200 μL |
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| USP7-SMARCA2-20-ORRE | 20 (40 μL) | 200 μL |
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| USP7-SMARCA2-20-OROR | 20 (40 μL) | 200 μL |
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| USP7-SMARCA2-20-ORGO | 20 (40 μL) | 200 μL |
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| USP7-SMARCA2-20-ORAQ | 20 (40 μL) | 200 μL |
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| USP7-SMARCA2-20-GORE | 20 (40 μL) | 200 μL |
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| USP7-SMARCA2-20-GOOR | 20 (40 μL) | 200 μL |
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| USP7-SMARCA2-20-GOGO | 20 (40 μL) | 200 μL |
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| USP7-SMARCA2-20-GOGR | 20 (40 μL) | 200 μL |
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| USP7-SMARCA2-20-GOAQ | 20 (40 μL) | 200 μL |
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| USP7-SMARCA2-20-GRRE | 20 (40 μL) | 200 μL |
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| USP7-SMARCA2-20-GROR | 20 (40 μL) | 200 μL |
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| USP7-SMARCA2-20-GRGO | 20 (40 μL) | 200 μL |
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| USP7-SMARCA2-20-GRGR | 20 (40 μL) | 200 μL |
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| USP7-SMARCA2-20-GRAQ | 20 (40 μL) | 200 μL |
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| USP7-SMARCA2-20-AQRE | 20 (40 μL) | 200 μL |
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| USP7-SMARCA2-20-AQOR | 20 (40 μL) | 200 μL |
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| USP7-SMARCA2-20-AQGO | 20 (40 μL) | 200 μL |
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| USP7-SMARCA2-20-AQGR | 20 (40 μL) | 200 μL |
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| USP7-SMARCA2-20-AQAQ | 20 (40 μL) | 200 μL |
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SMARCA2 Gene Summary
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. [provided by RefSeq, Jan 2014]
Gene Name: SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 2
Chromosome: CHR9: 2015341 -2193623
Locus: 9p24.3
USP7 Gene Summary
The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder. [provided by RefSeq, Mar 2016]
Gene Name: Ubiquitin Specific Peptidase 7
Chromosome: CHR16: 8985950 -9057341
Locus: 16p13.2
Gene Diseases
The USP7 SMARCA2 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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