USP53-MYOZ2 Fusion FISH Probe
The USP53-MYOZ2 Fusion FISH Probe is used to confirm a fusion of the USP53 and MYOZ2 genes. The fusion of the USP53 and MYOZ2 genes has been associated with Ovarian Serous Cystadenocarcinoma, and Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| USP53-MYOZ2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| USP53-MYOZ2-20-RERE | 20 (40 μL) | 200 μL |
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| USP53-MYOZ2-20-REOR | 20 (40 μL) | 200 μL |
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| USP53-MYOZ2-20-REGO | 20 (40 μL) | 200 μL |
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| USP53-MYOZ2-20-REGR | 20 (40 μL) | 200 μL |
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| USP53-MYOZ2-20-REAQ | 20 (40 μL) | 200 μL |
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| USP53-MYOZ2-20-ORRE | 20 (40 μL) | 200 μL |
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| USP53-MYOZ2-20-OROR | 20 (40 μL) | 200 μL |
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| USP53-MYOZ2-20-ORGO | 20 (40 μL) | 200 μL |
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| USP53-MYOZ2-20-ORAQ | 20 (40 μL) | 200 μL |
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| USP53-MYOZ2-20-GORE | 20 (40 μL) | 200 μL |
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| USP53-MYOZ2-20-GOOR | 20 (40 μL) | 200 μL |
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| USP53-MYOZ2-20-GOGO | 20 (40 μL) | 200 μL |
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| USP53-MYOZ2-20-GOGR | 20 (40 μL) | 200 μL |
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| USP53-MYOZ2-20-GOAQ | 20 (40 μL) | 200 μL |
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| USP53-MYOZ2-20-GRRE | 20 (40 μL) | 200 μL |
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| USP53-MYOZ2-20-GROR | 20 (40 μL) | 200 μL |
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| USP53-MYOZ2-20-GRGO | 20 (40 μL) | 200 μL |
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| USP53-MYOZ2-20-GRGR | 20 (40 μL) | 200 μL |
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| USP53-MYOZ2-20-GRAQ | 20 (40 μL) | 200 μL |
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| USP53-MYOZ2-20-AQRE | 20 (40 μL) | 200 μL |
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| USP53-MYOZ2-20-AQOR | 20 (40 μL) | 200 μL |
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| USP53-MYOZ2-20-AQGO | 20 (40 μL) | 200 μL |
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| USP53-MYOZ2-20-AQGR | 20 (40 μL) | 200 μL |
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| USP53-MYOZ2-20-AQAQ | 20 (40 μL) | 200 μL |
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MYOZ2 Gene Summary
The protein encoded by this gene belongs to a family of sarcomeric proteins that bind to calcineurin, a phosphatase involved in calcium-dependent signal transduction in diverse cell types. These family members tether calcineurin to alpha-actinin at the z-line of the sarcomere of cardiac and skeletal muscle cells, and thus they are important for calcineurin signaling. Mutations in this gene cause cardiomyopathy familial hypertrophic type 16, a hereditary heart disorder. [provided by RefSeq, Aug 2011]
Gene Name: Myozenin 2
Chromosome: CHR4: 120056938 -120108944
Locus: 4q26
USP53 Gene Summary
The Ubiquitin Specific Peptidase 53 (USP53) gene is located on chr4 :120133781-120216673 at 4q26.
Gene Name: Ubiquitin Specific Peptidase 53
Chromosome: CHR4: 120133781 -120216673
Locus: 4q26
Gene Diseases
The USP53 MYOZ2 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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