USP48-HSPG2 Fusion FISH Probe
The USP48-HSPG2 Fusion FISH Probe is used to confirm a fusion of the USP48 and HSPG2 genes. The fusion of the USP48 and HSPG2 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| USP48-HSPG2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| USP48-HSPG2-20-RERE | 20 (40 μL) | 200 μL |
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| USP48-HSPG2-20-REOR | 20 (40 μL) | 200 μL |
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| USP48-HSPG2-20-REGO | 20 (40 μL) | 200 μL |
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| USP48-HSPG2-20-REGR | 20 (40 μL) | 200 μL |
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| USP48-HSPG2-20-REAQ | 20 (40 μL) | 200 μL |
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| USP48-HSPG2-20-ORRE | 20 (40 μL) | 200 μL |
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| USP48-HSPG2-20-OROR | 20 (40 μL) | 200 μL |
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| USP48-HSPG2-20-ORGO | 20 (40 μL) | 200 μL |
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| USP48-HSPG2-20-ORAQ | 20 (40 μL) | 200 μL |
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| USP48-HSPG2-20-GORE | 20 (40 μL) | 200 μL |
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| USP48-HSPG2-20-GOOR | 20 (40 μL) | 200 μL |
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| USP48-HSPG2-20-GOGO | 20 (40 μL) | 200 μL |
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| USP48-HSPG2-20-GOGR | 20 (40 μL) | 200 μL |
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| USP48-HSPG2-20-GOAQ | 20 (40 μL) | 200 μL |
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| USP48-HSPG2-20-GRRE | 20 (40 μL) | 200 μL |
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| USP48-HSPG2-20-GROR | 20 (40 μL) | 200 μL |
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| USP48-HSPG2-20-GRGO | 20 (40 μL) | 200 μL |
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| USP48-HSPG2-20-GRGR | 20 (40 μL) | 200 μL |
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| USP48-HSPG2-20-GRAQ | 20 (40 μL) | 200 μL |
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| USP48-HSPG2-20-AQRE | 20 (40 μL) | 200 μL |
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| USP48-HSPG2-20-AQOR | 20 (40 μL) | 200 μL |
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| USP48-HSPG2-20-AQGO | 20 (40 μL) | 200 μL |
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| USP48-HSPG2-20-AQGR | 20 (40 μL) | 200 μL |
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| USP48-HSPG2-20-AQAQ | 20 (40 μL) | 200 μL |
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HSPG2 Gene Summary
This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and transthyretin, etc., and it plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and tardive dyskinesia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Name: Heparan Sulfate Proteoglycan 2
Chromosome: CHR1: 22148736 -22263750
Locus: 1p36.12
USP48 Gene Summary
This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: Ubiquitin Specific Peptidase 48
Chromosome: CHR1: 22004791 -22109688
Locus: 1p36.12
Gene Diseases
The USP48 HSPG2 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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