USP46-PDGFRA Fusion FISH Probe
The USP46-PDGFRA Fusion FISH Probe is used to confirm a fusion of the USP46 and PDGFRA genes. The fusion of the USP46 and PDGFRA genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| USP46-PDGFRA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| USP46-PDGFRA-20-RERE | 20 (40 μL) | 200 μL |
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| USP46-PDGFRA-20-REOR | 20 (40 μL) | 200 μL |
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| USP46-PDGFRA-20-REGO | 20 (40 μL) | 200 μL |
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| USP46-PDGFRA-20-REGR | 20 (40 μL) | 200 μL |
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| USP46-PDGFRA-20-REAQ | 20 (40 μL) | 200 μL |
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| USP46-PDGFRA-20-ORRE | 20 (40 μL) | 200 μL |
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| USP46-PDGFRA-20-OROR | 20 (40 μL) | 200 μL |
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| USP46-PDGFRA-20-ORGO | 20 (40 μL) | 200 μL |
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| USP46-PDGFRA-20-ORAQ | 20 (40 μL) | 200 μL |
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| USP46-PDGFRA-20-GORE | 20 (40 μL) | 200 μL |
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| USP46-PDGFRA-20-GOOR | 20 (40 μL) | 200 μL |
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| USP46-PDGFRA-20-GOGO | 20 (40 μL) | 200 μL |
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| USP46-PDGFRA-20-GOGR | 20 (40 μL) | 200 μL |
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| USP46-PDGFRA-20-GOAQ | 20 (40 μL) | 200 μL |
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| USP46-PDGFRA-20-GRRE | 20 (40 μL) | 200 μL |
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| USP46-PDGFRA-20-GROR | 20 (40 μL) | 200 μL |
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| USP46-PDGFRA-20-GRGO | 20 (40 μL) | 200 μL |
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| USP46-PDGFRA-20-GRGR | 20 (40 μL) | 200 μL |
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| USP46-PDGFRA-20-GRAQ | 20 (40 μL) | 200 μL |
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| USP46-PDGFRA-20-AQRE | 20 (40 μL) | 200 μL |
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| USP46-PDGFRA-20-AQOR | 20 (40 μL) | 200 μL |
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| USP46-PDGFRA-20-AQGO | 20 (40 μL) | 200 μL |
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| USP46-PDGFRA-20-AQGR | 20 (40 μL) | 200 μL |
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| USP46-PDGFRA-20-AQAQ | 20 (40 μL) | 200 μL |
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PDGFRA Gene Summary
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]
Gene Name: Platelet Derived Growth Factor Receptor Alpha
Chromosome: CHR4: 55095263 -55164412
Locus: 4q12
USP46 Gene Summary
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Jun 2009]
Gene Name: Ubiquitin Specific Peptidase 46
Chromosome: CHR4: 53457126 -53525502
Locus: 4q12
Gene Diseases
The USP46 PDGFRA Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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