USP45-ASCC3 Fusion FISH Probe
The USP45-ASCC3 Fusion FISH Probe is used to confirm a fusion of the USP45 and ASCC3 genes. The fusion of the USP45 and ASCC3 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| USP45-ASCC3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| USP45-ASCC3-20-RERE | 20 (40 μL) | 200 μL |
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| USP45-ASCC3-20-REOR | 20 (40 μL) | 200 μL |
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| USP45-ASCC3-20-REGO | 20 (40 μL) | 200 μL |
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| USP45-ASCC3-20-REGR | 20 (40 μL) | 200 μL |
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| USP45-ASCC3-20-REAQ | 20 (40 μL) | 200 μL |
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| USP45-ASCC3-20-ORRE | 20 (40 μL) | 200 μL |
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| USP45-ASCC3-20-OROR | 20 (40 μL) | 200 μL |
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| USP45-ASCC3-20-ORGO | 20 (40 μL) | 200 μL |
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| USP45-ASCC3-20-ORAQ | 20 (40 μL) | 200 μL |
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| USP45-ASCC3-20-GORE | 20 (40 μL) | 200 μL |
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| USP45-ASCC3-20-GOOR | 20 (40 μL) | 200 μL |
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| USP45-ASCC3-20-GOGO | 20 (40 μL) | 200 μL |
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| USP45-ASCC3-20-GOGR | 20 (40 μL) | 200 μL |
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| USP45-ASCC3-20-GOAQ | 20 (40 μL) | 200 μL |
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| USP45-ASCC3-20-GRRE | 20 (40 μL) | 200 μL |
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| USP45-ASCC3-20-GROR | 20 (40 μL) | 200 μL |
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| USP45-ASCC3-20-GRGO | 20 (40 μL) | 200 μL |
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| USP45-ASCC3-20-GRGR | 20 (40 μL) | 200 μL |
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| USP45-ASCC3-20-GRAQ | 20 (40 μL) | 200 μL |
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| USP45-ASCC3-20-AQRE | 20 (40 μL) | 200 μL |
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| USP45-ASCC3-20-AQOR | 20 (40 μL) | 200 μL |
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| USP45-ASCC3-20-AQGO | 20 (40 μL) | 200 μL |
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| USP45-ASCC3-20-AQGR | 20 (40 μL) | 200 μL |
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| USP45-ASCC3-20-AQAQ | 20 (40 μL) | 200 μL |
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ASCC3 Gene Summary
This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Name: Activating Signal Cointegrator 1 Complex Subunit 3
Chromosome: CHR6: 100956607 -101329224
Locus: 6q16.3
USP45 Gene Summary
The protein encoded by this gene is a deubiquitylase that binds ERCC1, the catalytic subunit of the XPF-ERCC1 DNA repair endonuclease. This endonuclease is a critical regulator of DNA repair processes, and the deubiquitylase activity of the encoded protein is important for maintaining the DNA repair ability of XPF-ERCC1. [provided by RefSeq, Sep 2016]
Gene Name: Ubiquitin Specific Peptidase 45
Chromosome: CHR6: 99880183 -99963252
Locus: 6q16.2
Gene Diseases
The USP45 ASCC3 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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