USP35-CHRDL2 Fusion FISH Probe
The USP35-CHRDL2 Fusion FISH Probe is used to confirm a fusion of the USP35 and CHRDL2 genes. The fusion of the USP35 and CHRDL2 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| USP35-CHRDL2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| USP35-CHRDL2-20-RERE | 20 (40 μL) | 200 μL |
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| USP35-CHRDL2-20-REOR | 20 (40 μL) | 200 μL |
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| USP35-CHRDL2-20-REGO | 20 (40 μL) | 200 μL |
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| USP35-CHRDL2-20-REGR | 20 (40 μL) | 200 μL |
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| USP35-CHRDL2-20-REAQ | 20 (40 μL) | 200 μL |
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| USP35-CHRDL2-20-ORRE | 20 (40 μL) | 200 μL |
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| USP35-CHRDL2-20-OROR | 20 (40 μL) | 200 μL |
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| USP35-CHRDL2-20-ORGO | 20 (40 μL) | 200 μL |
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| USP35-CHRDL2-20-ORAQ | 20 (40 μL) | 200 μL |
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| USP35-CHRDL2-20-GORE | 20 (40 μL) | 200 μL |
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| USP35-CHRDL2-20-GOOR | 20 (40 μL) | 200 μL |
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| USP35-CHRDL2-20-GOGO | 20 (40 μL) | 200 μL |
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| USP35-CHRDL2-20-GOGR | 20 (40 μL) | 200 μL |
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| USP35-CHRDL2-20-GOAQ | 20 (40 μL) | 200 μL |
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| USP35-CHRDL2-20-GRRE | 20 (40 μL) | 200 μL |
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| USP35-CHRDL2-20-GROR | 20 (40 μL) | 200 μL |
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| USP35-CHRDL2-20-GRGO | 20 (40 μL) | 200 μL |
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| USP35-CHRDL2-20-GRGR | 20 (40 μL) | 200 μL |
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| USP35-CHRDL2-20-GRAQ | 20 (40 μL) | 200 μL |
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| USP35-CHRDL2-20-AQRE | 20 (40 μL) | 200 μL |
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| USP35-CHRDL2-20-AQOR | 20 (40 μL) | 200 μL |
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| USP35-CHRDL2-20-AQGO | 20 (40 μL) | 200 μL |
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| USP35-CHRDL2-20-AQGR | 20 (40 μL) | 200 μL |
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| USP35-CHRDL2-20-AQAQ | 20 (40 μL) | 200 μL |
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CHRDL2 Gene Summary
This gene encodes a member of the chordin family of proteins. Chordin family members are secreted proteins that share a cysteine-rich pro-collagen repeat domain and associate with members of the transforming growth factor beta superfamily. In vitro assays demonstrate a direct interaction between the encoded protein and human activin A. This gene is expressed in many tissues including osteoblasts, where it is differentially expressed during differentiation. In addition, its expression is upregulated in human osteoarthritic joint cartilage, suggesting a role in adult cartilage regeneration. [provided by RefSeq, Jan 2015]
Gene Name: Chordin Like 2
Chromosome: CHR11: 74407473 -74442186
Locus: 11q13.4
USP35 Gene Summary
This gene encodes a member of the peptidase C19 family of ubiquitin-specific proteases. These deubiquitinating enzymes (DUBs) catalyze the removal of ubiquitin proteins from other proteins. The encoded protein associates with polarized mitochondria and has been shown to inhibit NF-kappa B activation and delay PARK2-mediated degradation of mitochondria. Expression of this gene is upregulated by the let-7a microRNA and reduced expression has been observed in human tumor tissues. [provided by RefSeq, Jul 2017]
Gene Name: Ubiquitin Specific Peptidase 35
Chromosome: CHR11: 77899857 -77925757
Locus: 11q14.1
Gene Diseases
The USP35 CHRDL2 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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