USP25-PCNT Fusion FISH Probe
The USP25-PCNT Fusion FISH Probe is used to confirm a fusion of the USP25 and PCNT genes. The fusion of the USP25 and PCNT genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| USP25-PCNT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| USP25-PCNT-20-RERE | 20 (40 μL) | 200 μL |
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| USP25-PCNT-20-REOR | 20 (40 μL) | 200 μL |
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| USP25-PCNT-20-REGO | 20 (40 μL) | 200 μL |
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| USP25-PCNT-20-REGR | 20 (40 μL) | 200 μL |
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| USP25-PCNT-20-REAQ | 20 (40 μL) | 200 μL |
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| USP25-PCNT-20-ORRE | 20 (40 μL) | 200 μL |
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| USP25-PCNT-20-OROR | 20 (40 μL) | 200 μL |
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| USP25-PCNT-20-ORGO | 20 (40 μL) | 200 μL |
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| USP25-PCNT-20-ORAQ | 20 (40 μL) | 200 μL |
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| USP25-PCNT-20-GORE | 20 (40 μL) | 200 μL |
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| USP25-PCNT-20-GOOR | 20 (40 μL) | 200 μL |
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| USP25-PCNT-20-GOGO | 20 (40 μL) | 200 μL |
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| USP25-PCNT-20-GOGR | 20 (40 μL) | 200 μL |
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| USP25-PCNT-20-GOAQ | 20 (40 μL) | 200 μL |
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| USP25-PCNT-20-GRRE | 20 (40 μL) | 200 μL |
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| USP25-PCNT-20-GROR | 20 (40 μL) | 200 μL |
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| USP25-PCNT-20-GRGO | 20 (40 μL) | 200 μL |
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| USP25-PCNT-20-GRGR | 20 (40 μL) | 200 μL |
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| USP25-PCNT-20-GRAQ | 20 (40 μL) | 200 μL |
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| USP25-PCNT-20-AQRE | 20 (40 μL) | 200 μL |
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| USP25-PCNT-20-AQOR | 20 (40 μL) | 200 μL |
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| USP25-PCNT-20-AQGO | 20 (40 μL) | 200 μL |
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| USP25-PCNT-20-AQGR | 20 (40 μL) | 200 μL |
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| USP25-PCNT-20-AQAQ | 20 (40 μL) | 200 μL |
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PCNT Gene Summary
The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Gene Name: Pericentrin
Chromosome: CHR21: 47744035 -47865682
Locus: 21q22.3
USP25 Gene Summary
Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM, Mar 2008]
Gene Name: Ubiquitin Specific Peptidase 25
Chromosome: CHR21: 17102495 -17252377
Locus: 21q21.1
Gene Diseases
The USP25 PCNT Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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