USP25-CAPN3 Fusion FISH Probe
The USP25-CAPN3 Fusion FISH Probe is used to confirm a fusion of the USP25 and CAPN3 genes. The fusion of the USP25 and CAPN3 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| USP25-CAPN3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| USP25-CAPN3-20-RERE | 20 (40 μL) | 200 μL |
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| USP25-CAPN3-20-REOR | 20 (40 μL) | 200 μL |
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| USP25-CAPN3-20-REGO | 20 (40 μL) | 200 μL |
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| USP25-CAPN3-20-REGR | 20 (40 μL) | 200 μL |
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| USP25-CAPN3-20-REAQ | 20 (40 μL) | 200 μL |
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| USP25-CAPN3-20-ORRE | 20 (40 μL) | 200 μL |
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| USP25-CAPN3-20-OROR | 20 (40 μL) | 200 μL |
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| USP25-CAPN3-20-ORGO | 20 (40 μL) | 200 μL |
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| USP25-CAPN3-20-ORAQ | 20 (40 μL) | 200 μL |
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| USP25-CAPN3-20-GORE | 20 (40 μL) | 200 μL |
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| USP25-CAPN3-20-GOOR | 20 (40 μL) | 200 μL |
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| USP25-CAPN3-20-GOGO | 20 (40 μL) | 200 μL |
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| USP25-CAPN3-20-GOGR | 20 (40 μL) | 200 μL |
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| USP25-CAPN3-20-GOAQ | 20 (40 μL) | 200 μL |
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| USP25-CAPN3-20-GRRE | 20 (40 μL) | 200 μL |
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| USP25-CAPN3-20-GROR | 20 (40 μL) | 200 μL |
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| USP25-CAPN3-20-GRGO | 20 (40 μL) | 200 μL |
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| USP25-CAPN3-20-GRGR | 20 (40 μL) | 200 μL |
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| USP25-CAPN3-20-GRAQ | 20 (40 μL) | 200 μL |
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| USP25-CAPN3-20-AQRE | 20 (40 μL) | 200 μL |
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| USP25-CAPN3-20-AQOR | 20 (40 μL) | 200 μL |
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| USP25-CAPN3-20-AQGO | 20 (40 μL) | 200 μL |
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| USP25-CAPN3-20-AQGR | 20 (40 μL) | 200 μL |
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| USP25-CAPN3-20-AQAQ | 20 (40 μL) | 200 μL |
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CAPN3 Gene Summary
Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed. [provided by RefSeq, Jul 2008]
Gene Name: Calpain 3
Chromosome: CHR15: 42651697 -42704515
Locus: 15q15.1
USP25 Gene Summary
Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM, Mar 2008]
Gene Name: Ubiquitin Specific Peptidase 25
Chromosome: CHR21: 17102495 -17252377
Locus: 21q21.1
Gene Diseases
The USP25 CAPN3 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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