USP18-YWHAH Fusion FISH Probe
The USP18-YWHAH Fusion FISH Probe is used to confirm a fusion of the USP18 and YWHAH genes. The fusion of the USP18 and YWHAH genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| USP18-YWHAH-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| USP18-YWHAH-20-RERE | 20 (40 μL) | 200 μL |
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| USP18-YWHAH-20-REOR | 20 (40 μL) | 200 μL |
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| USP18-YWHAH-20-REGO | 20 (40 μL) | 200 μL |
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| USP18-YWHAH-20-REGR | 20 (40 μL) | 200 μL |
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| USP18-YWHAH-20-REAQ | 20 (40 μL) | 200 μL |
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| USP18-YWHAH-20-ORRE | 20 (40 μL) | 200 μL |
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| USP18-YWHAH-20-OROR | 20 (40 μL) | 200 μL |
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| USP18-YWHAH-20-ORGO | 20 (40 μL) | 200 μL |
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| USP18-YWHAH-20-ORAQ | 20 (40 μL) | 200 μL |
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| USP18-YWHAH-20-GORE | 20 (40 μL) | 200 μL |
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| USP18-YWHAH-20-GOOR | 20 (40 μL) | 200 μL |
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| USP18-YWHAH-20-GOGO | 20 (40 μL) | 200 μL |
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| USP18-YWHAH-20-GOGR | 20 (40 μL) | 200 μL |
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| USP18-YWHAH-20-GOAQ | 20 (40 μL) | 200 μL |
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| USP18-YWHAH-20-GRRE | 20 (40 μL) | 200 μL |
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| USP18-YWHAH-20-GROR | 20 (40 μL) | 200 μL |
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| USP18-YWHAH-20-GRGO | 20 (40 μL) | 200 μL |
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| USP18-YWHAH-20-GRGR | 20 (40 μL) | 200 μL |
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| USP18-YWHAH-20-GRAQ | 20 (40 μL) | 200 μL |
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| USP18-YWHAH-20-AQRE | 20 (40 μL) | 200 μL |
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| USP18-YWHAH-20-AQOR | 20 (40 μL) | 200 μL |
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| USP18-YWHAH-20-AQGO | 20 (40 μL) | 200 μL |
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| USP18-YWHAH-20-AQGR | 20 (40 μL) | 200 μL |
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| USP18-YWHAH-20-AQAQ | 20 (40 μL) | 200 μL |
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YWHAH Gene Summary
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]
Gene Name: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase Activation Protein Eta
Chromosome: CHR22: 32340478 -32353590
Locus: 22q12.3
USP18 Gene Summary
The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011]
Gene Name: Ubiquitin Specific Peptidase 18
Chromosome: CHR22: 18632757 -18660162
Locus: 22q11.21
Gene Diseases
The USP18 YWHAH Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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